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smad4 [nucleoplasm]
Stable Identifier
R-XTR-177103
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
nucleoplasm
Synonyms
SMAD4, A0A8J0QJT5
Locations in the PathwayBrowser
Expand all
Developmental Biology (Xenopus tropicalis)
Signaling by NODAL (Xenopus tropicalis)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Xenopus tropicalis)
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
Gene expression (Transcription) (Xenopus tropicalis)
RNA Polymerase II Transcription (Xenopus tropicalis)
Generic Transcription Pathway (Xenopus tropicalis)
FOXO-mediated transcription (Xenopus tropicalis)
FOXO-mediated transcription of cell cycle genes (Xenopus tropicalis)
FOXG1 binds FOXO:SMAD complexes (Xenopus tropicalis)
FOXG1:FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Xenopus tropicalis)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Xenopus tropicalis)
FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Xenopus tropicalis)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Xenopus tropicalis)
Degradation of SMAD2/3:SMAD4 complex (Xenopus tropicalis)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Xenopus tropicalis)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
PPM1A dephosphorylates nuclear SMAD2/3 (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
SMURF2 binds SMAD3 phosphorylated in the linker region (Xenopus tropicalis)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Xenopus tropicalis)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
SMURF2 monoubiquitinates SMAD3 (Xenopus tropicalis)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Xenopus tropicalis)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Xenopus tropicalis)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
WWTR1:SMAD translocates to the nucleus (Xenopus tropicalis)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
Transcriptional regulation by RUNX2 (Xenopus tropicalis)
RUNX2 regulates bone development (Xenopus tropicalis)
RUNX2 binds SMAD1 in the nucleus (Xenopus tropicalis)
RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
Signal Transduction (Xenopus tropicalis)
Signaling by TGFB family members (Xenopus tropicalis)
Signaling by Activin (Xenopus tropicalis)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
Signaling by BMP (Xenopus tropicalis)
SKI complexes with the Smad complex, suppressing BMP2 signalling (Xenopus tropicalis)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD1/5/8:SMAD4:SKI [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Xenopus tropicalis)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
Signaling by TGF-beta Receptor Complex (Xenopus tropicalis)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Xenopus tropicalis)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Xenopus tropicalis)
Degradation of SMAD2/3:SMAD4 complex (Xenopus tropicalis)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Xenopus tropicalis)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
PPM1A dephosphorylates nuclear SMAD2/3 (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
SMURF2 binds SMAD3 phosphorylated in the linker region (Xenopus tropicalis)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Xenopus tropicalis)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
SMURF2 monoubiquitinates SMAD3 (Xenopus tropicalis)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Xenopus tropicalis)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Xenopus tropicalis)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Xenopus tropicalis)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
WWTR1:SMAD translocates to the nucleus (Xenopus tropicalis)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
smad4 [nucleoplasm] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:A0A8J0QJT5
Gene Names
smad4
Reference Genes
BioGPS Gene:100038088 smad4
ENSEMBL:ENSXETG00000022355
KEGG:xtr:100038088 smad4
Monarch:100038088 smad4
NCBI Gene:100038088 smad4
UCSC:A0A8J0QJT5 smad4
Reference Transcript
RefSeq:XM_002934439.5 smad4
Participates
as a component of
p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Xenopus tropicalis)
p-T,2S-SMAD2:p-T,2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm] (Xenopus tropicalis)
as an output of
PPM1A dephosphorylates nuclear SMAD2/3 (Xenopus tropicalis)
SMURF2 monoubiquitinates SMAD3 (Xenopus tropicalis)
Other forms of this molecule
phospho-smad4 [nucleoplasm]
smad4 [nucleoplasm]
smad4 [cytosol]
smad4 [cytosol]
Inferred From
SMAD4 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_002934485.1
Xenbase
XB-GENE-485691
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