Reactome | cdc23 [cytosol]

cdc23 [cytosol]

Stable Identifier

R-XTR-174137

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

CDC23, Q28D09

Locations in the PathwayBrowser

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Cell Cycle (Xenopus tropicalis)

- Cell Cycle Checkpoints (Xenopus tropicalis)
  - Mitotic Spindle Checkpoint (Xenopus tropicalis)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Xenopus tropicalis)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Xenopus tropicalis)
        
        Binding of the MCC complex to the APC/C complex (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
- Cell Cycle, Mitotic (Xenopus tropicalis)
  - M Phase (Xenopus tropicalis)
    - Mitotic Metaphase and Anaphase (Xenopus tropicalis)
      - Mitotic Anaphase (Xenopus tropicalis)
        
        Separation of Sister Chromatids (Xenopus tropicalis)
        
        Association of Securin with Cdc20:APC/C complex (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Degradation of multiubiquitinated Securin (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
  - Regulation of mitotic cell cycle (Xenopus tropicalis)
    - APC/C-mediated degradation of cell cycle proteins (Xenopus tropicalis)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Xenopus tropicalis)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Xenopus tropicalis)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Degradation of multiubiquitinated cell cycle proteins (Xenopus tropicalis)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Xenopus tropicalis)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Xenopus tropicalis)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Xenopus tropicalis)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Xenopus tropicalis)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Degradation of multiubiquitinated Cyclin B (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Xenopus tropicalis)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Xenopus tropicalis)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        APC/C:Cdc20 mediated degradation of Securin (Xenopus tropicalis)
        
        Association of Securin with Cdc20:APC/C complex (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Degradation of multiubiquitinated Securin (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Xenopus tropicalis)
        
        APC-Cdc20 mediated degradation of Nek2A (Xenopus tropicalis)
        
        Degradation of multiubiquitinated Nek2A (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Multiubiquitinated Nek2A [cytosol] (Xenopus tropicalis)
        
        Nek2A:MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Multiubiquitination of Nek2A (Xenopus tropicalis)
        
        Multiubiquitinated Nek2A [cytosol] (Xenopus tropicalis)
        
        Nek2A:MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Nek2A:MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Xenopus tropicalis)
        
        Association of Cyclin A with the APC/C (Xenopus tropicalis)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Degradation multiubiquitinated Cyclin A (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Xenopus tropicalis)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Xenopus tropicalis)
        
        Association of Cdh1 with the APC/C (Xenopus tropicalis)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        Dissociation of Cdc20 from APC/C complex (Xenopus tropicalis)
        
        CDC20:p-APC/C [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
      - Regulation of APC/C activators between G1/S and early anaphase (Xenopus tropicalis)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Xenopus tropicalis)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Xenopus tropicalis)
        
        Binding of the MCC complex to the APC/C complex (Xenopus tropicalis)
        
        MCC:APC/C complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)
  - S Phase (Xenopus tropicalis)
    - Synthesis of DNA (Xenopus tropicalis)
      - Switching of origins to a post-replicative state (Xenopus tropicalis)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Xenopus tropicalis)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Xenopus tropicalis)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Xenopus tropicalis)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Xenopus tropicalis)
        
        cdc23 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q28D09

Gene Names

cdc23

Reference Genes

BioGPS Gene:549513 cdc23

ENSEMBL:ENSXETG00000006716

KEGG:xtr:549513 cdc23

Monarch:549513 cdc23

NCBI Gene:549513 cdc23

UCSC:Q28D09 cdc23

Reference Transcript

RefSeq:NM_001016759.2 cdc23

Other Identifiers

549513

GO:0005680

GO:0016567

GO:0030163

GO:0031145

GO:0045842

GO:0051301

Participates

as a component of

Other forms of this molecule

cdc23 [nucleoplasm]

Inferred From

CDC23 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001016759.1

ENSEMBL

ENSXETT00000014690, ENSXETG00000006716, ENSXETP00000014690

Xenbase

XB-GENE-1015904

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