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phospho-p-Y55,Y227-SPRY2 [plasma membrane]
Stable Identifier
R-SSC-934555
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
plasma membrane
Synonyms
F1RP67
Locations in the PathwayBrowser
Expand all
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by FGFR (Sus scrofa)
Signaling by FGFR1 (Sus scrofa)
Negative regulation of FGFR1 signaling (Sus scrofa)
Spry regulation of FGF signaling (Sus scrofa)
CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
PPTN11 dephosphorylates SPRY2 (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
SPRY2 binds CBL (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
SPRY2 binds GRB2 (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
SRC phosphorylates SPRY2 on Y55 and Y227 (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Signaling by FGFR2 (Sus scrofa)
Negative regulation of FGFR2 signaling (Sus scrofa)
Spry regulation of FGF signaling (Sus scrofa)
CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
PPTN11 dephosphorylates SPRY2 (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
SPRY2 binds CBL (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
SPRY2 binds GRB2 (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
SRC phosphorylates SPRY2 on Y55 and Y227 (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Signaling by FGFR3 (Sus scrofa)
Negative regulation of FGFR3 signaling (Sus scrofa)
Spry regulation of FGF signaling (Sus scrofa)
CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
PPTN11 dephosphorylates SPRY2 (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
SPRY2 binds CBL (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
SPRY2 binds GRB2 (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
SRC phosphorylates SPRY2 on Y55 and Y227 (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Signaling by FGFR4 (Sus scrofa)
Negative regulation of FGFR4 signaling (Sus scrofa)
Spry regulation of FGF signaling (Sus scrofa)
CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
PPTN11 dephosphorylates SPRY2 (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
SPRY2 binds CBL (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
SPRY2 binds GRB2 (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
SRC phosphorylates SPRY2 on Y55 and Y227 (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
phospho-p-Y55,Y227-SPRY2 [plasma membrane] (Sus scrofa)
External Reference Information
External Reference
UniProt:F1RP67
Reference Genes
BioGPS Gene:100157266
ENSEMBL:ENSSSCG00000009482.4
ENSEMBL:ENSSSCG00005029787.1
KEGG Gene (Sus scrofa):100157266
Monarch:100157266
NCBI Gene:100157266
Reference Transcript
RefSeq:XM_001927097.4
Participates
as a component of
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Sus scrofa)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Sus scrofa)
PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] (Sus scrofa)
Other forms of this molecule
phospho-p-Y55-SPRY2 [cytosol]
phospho-p-S111,S120-SPRY2 [cytosol]
phospho-p-S112,S115-SPRY2 [cytosol]
SPRY2 [cytosol]
phospho-p-S112,S121-SPRY2 [plasma membrane]
SPRY2 [plasma membrane]
Inferred From
p-Y55,Y227-SPRY2 [plasma membrane]
(Homo sapiens)
p-Y55,Y227-SPRY2 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 55 (in Homo sapiens)
Coordinate
55
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 227 (in Homo sapiens)
Coordinate
227
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_001927132.1
VGNC
93425
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