Reactome | ORC4 [nucleoplasm]

ORC4 [nucleoplasm]

Stable Identifier

R-SSC-68519

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

ORC4, F1S0H7

Locations in the PathwayBrowser

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Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - G2/M Checkpoints (Sus scrofa)
    - Activation of ATR in response to replication stress (Sus scrofa)
      - Activation of claspin (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
      - Loading of claspin onto DNA during replication origin firing (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
- Cell Cycle, Mitotic (Sus scrofa)
  - Mitotic G1 phase and G1/S transition (Sus scrofa)
    - G1/S Transition (Sus scrofa)
      - Activation of the pre-replicative complex (Sus scrofa)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase binds at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon binds at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
        
        MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
  - S Phase (Sus scrofa)
    - Synthesis of DNA (Sus scrofa)
      - Switching of origins to a post-replicative state (Sus scrofa)
        
        Orc1 removal from chromatin (Sus scrofa)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)

DNA Replication (Sus scrofa)

- DNA Replication Pre-Initiation (Sus scrofa)
  - Activation of the pre-replicative complex (Sus scrofa)
    - CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
      - MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
    - Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
    - Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)
      - MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
      - MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
    - DNA polymerase alpha:primase binds at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
    - DNA polymerase epsilon binds at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
      - MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
      - pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
  - Assembly of the pre-replicative complex (Sus scrofa)
    - Assembly of the ORC complex at the origin of replication (Sus scrofa)
      - Formation of ORC(1-5) complex (Sus scrofa)
        
        ORC(1-5):origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC(1-5) [nucleoplasm] (Sus scrofa)
        
        ORC(2-5) [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        ORC(2-5) [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
      - Formation of ORC(1-6) complex (Sus scrofa)
        
        ORC(1-5):origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC(1-5) [nucleoplasm] (Sus scrofa)
        
        ORC(2-5) [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        ORC(1-6):origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC(1-5):origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC(1-5) [nucleoplasm] (Sus scrofa)
        
        ORC(2-5) [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
      - Formation of ORC(2-5) complex (Sus scrofa)
        
        ORC(2-5) [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
    - CDC6 association with the ORC:origin complex (Sus scrofa)
      - CDC6 association with ORC(1-6) at replication origins (Sus scrofa)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC(1-6):origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC(1-5):origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC(1-5) [nucleoplasm] (Sus scrofa)
        
        ORC(2-5) [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        ORC(1-6):origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC(1-5):origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC(1-5) [nucleoplasm] (Sus scrofa)
        
        ORC(2-5) [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
- Synthesis of DNA (Sus scrofa)
  - Switching of origins to a post-replicative state (Sus scrofa)
    - Orc1 removal from chromatin (Sus scrofa)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC4 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1S0H7

Gene Names

ORC4

Reference Genes

BioGPS Gene:100519056 ORC4

ENSEMBL:ENSSSCG00000015668.5

ENSEMBL:ENSSSCG00005012412.1 ORC4

KEGG Gene (Sus scrofa):100519056 ORC4

Monarch:100519056 ORC4

NCBI Gene:100519056 ORC4

Reference Transcript

Other Identifiers

100519056

GO:0000166

GO:0000228

GO:0000781

GO:0000808

GO:0000910

GO:0003677

GO:0003688

GO:0003824

GO:0005634

GO:0005654

GO:0005664

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006260

GO:0006270

GO:0016787

GO:0016887

GO:0022414

GO:0040038

GO:0043226

GO:0051258

GO:0065003

GO:0140013

GO:0140657

Ssc.29169.1.A1_at

Participates

as a component of

as an input of

Formation of ORC(2-5) complex (Sus scrofa)

Inferred From

ORC4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_005671660.1, XP_005671661.1, XP_013839382.1, XP_003133297.1

OpenTargets

ENSG00000115947

Ensembl

ENSSSCP00000016611, ENSSSCG00000015668, ENSSSCT00000017066

VGNC

96465

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