Reactome | POLA1 [nucleoplasm]

POLA1 [nucleoplasm]

Stable Identifier

R-SSC-68487

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

POLA1, A0A480JGU4

Locations in the PathwayBrowser

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Cell Cycle (Sus scrofa)

- Cell Cycle, Mitotic (Sus scrofa)
  - Mitotic G1 phase and G1/S transition (Sus scrofa)
    - G1/S Transition (Sus scrofa)
      - Activation of the pre-replicative complex (Sus scrofa)
        
        DNA polymerase alpha:primase binds at the origin (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
      - E2F mediated regulation of DNA replication (Sus scrofa)
        
        Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Sus scrofa)
        
        Detection of damage during initiation of DNA synthesis in S-phase (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
  - S Phase (Sus scrofa)
    - Synthesis of DNA (Sus scrofa)
      - DNA replication initiation (Sus scrofa)
        
        The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
      - DNA strand elongation (Sus scrofa)
        
        Lagging Strand Synthesis (Sus scrofa)
        
        Polymerase switching (Sus scrofa)
        
        Formation of Processive Complex (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Loading of PCNA - Sliding Clamp Formation (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RFC binding displaces Pol Alpha (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RFC dissociates after sliding clamp formation (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive synthesis on the lagging strand (Sus scrofa)
        
        Formation of Okazaki fragments (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Formation of the Flap Intermediate (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Removal of the Flap Intermediate (Sus scrofa)
        
        RPA binds to the Flap (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Recruitment of Dna2 endonuclease (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Removal of RNA primer and dissociation of RPA and Dna2 (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Removal of remaining Flap (Sus scrofa)
        
        Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive complex:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Leading Strand Synthesis (Sus scrofa)
        
        Polymerase switching (Sus scrofa)
        
        Formation of Processive Complex (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Loading of PCNA - Sliding Clamp Formation (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RFC binding displaces Pol Alpha (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RFC dissociates after sliding clamp formation (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
- Chromosome Maintenance (Sus scrofa)
  - Telomere Maintenance (Sus scrofa)
    - Extension of Telomeres (Sus scrofa)
      - Telomere C-strand (Lagging Strand) Synthesis (Sus scrofa)
        
        Polymerase switching on the C-strand of the telomere (Sus scrofa)
        
        RFC binding displaces Pol Alpha on the C-strand of the telomere (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Sus scrofa)
        
        RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Telomere C-strand synthesis initiation (Sus scrofa)
        
        DNA polymerase:primase binds G-strand of the telomere (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        POLA:primase:G-strand extended telomere end [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Sus scrofa)
        
        RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Sus scrofa)
        
        POLA:primase:G-strand extended telomere end [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)

DNA Replication (Sus scrofa)

- DNA Replication Pre-Initiation (Sus scrofa)
  - Activation of the pre-replicative complex (Sus scrofa)
    - DNA polymerase alpha:primase binds at the origin (Sus scrofa)
      - DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
      - DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
- Synthesis of DNA (Sus scrofa)
  - DNA replication initiation (Sus scrofa)
    - The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Sus scrofa)
      - DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
      - RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
      - RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
    - The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Sus scrofa)
      - DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
      - DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
      - RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
  - DNA strand elongation (Sus scrofa)
    - Lagging Strand Synthesis (Sus scrofa)
      - Polymerase switching (Sus scrofa)
        
        Formation of Processive Complex (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Loading of PCNA - Sliding Clamp Formation (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RFC binding displaces Pol Alpha (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RFC dissociates after sliding clamp formation (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
      - Processive synthesis on the lagging strand (Sus scrofa)
        
        Formation of Okazaki fragments (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Formation of the Flap Intermediate (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Removal of the Flap Intermediate (Sus scrofa)
        
        RPA binds to the Flap (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Recruitment of Dna2 endonuclease (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Removal of RNA primer and dissociation of RPA and Dna2 (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Removal of remaining Flap (Sus scrofa)
        
        Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Processive complex:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
    - Leading Strand Synthesis (Sus scrofa)
      - Polymerase switching (Sus scrofa)
        
        Formation of Processive Complex (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        Loading of PCNA - Sliding Clamp Formation (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RFC binding displaces Pol Alpha (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RFC dissociates after sliding clamp formation (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (Sus scrofa)
        
        RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (Sus scrofa)
        
        RNA primer-DNA primer:origin duplex [nucleoplasm] (Sus scrofa)
        
        RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)
        
        POLA1 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A480JGU4

Gene Names

POLA1

Reference Genes

BioGPS Gene:102166485 POLA1

ENSEMBL:ENSSSCG00000022240.5

KEGG:ssc:102166485 POLA1

Monarch:102166485 POLA1

NCBI Gene:102166485 POLA1

UCSC:A0A480JGU4 POLA1

Reference Transcript

RefSeq:XM_021080571.1 POLA1

Other Identifiers

GO:0000166

GO:0003676

GO:0003677

GO:0003682

GO:0003688

GO:0003697

GO:0003824

GO:0003887

GO:0005634

GO:0005654

GO:0005658

GO:0005737

GO:0005829

GO:0006260

GO:0006269

GO:0006270

GO:0006272

GO:0006273

GO:0008270

GO:0016740

GO:0016779

GO:0046872

GO:0071897

GO:0140097

GO:1902975

Participates

as a component of

DNA polymerase alpha:primase [nucleoplasm] (Sus scrofa)

Inferred From

POLA1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_020936230.1

ENSEMBL

ENSSSCP00000071193, ENSSSCT00000083672, ENSSSCG00000022240

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