Reactome | TNFSF11 [plasma membrane]

TNFSF11 [plasma membrane]

Stable Identifier

R-SSC-5667141

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

TNFSF11, F1RJX1

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - TNFR2 non-canonical NF-kB pathway (Sus scrofa)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
    - Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)
      - TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Sus scrofa)
      - 2xRANK binds RANKL,sRANKL trimer:RANK (Sus scrofa)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
        
        RANK:RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
      - RANKL,sRANKL trimer binds RANK (Sus scrofa)
        
        RANK:RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
      - TRAFs bind RANK:RANKL (Sus scrofa)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
        
        3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
    - TNFs bind their physiological receptors (Sus scrofa)
      - TNFSF11 binds TNFRSF11A, B (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
        
        TNFSF11,sTNFSF11 trimer:3xTNFRSF11B [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Sus scrofa)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Sus scrofa)
        
        3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Sus scrofa)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Sus scrofa)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Sus scrofa)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL,sRANKL trimer [plasma membrane] (Sus scrofa)
        
        RANKL trimer [plasma membrane] (Sus scrofa)
        
        TNFSF11 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RJX1

Gene Names

TNFSF11

Reference Genes

BioGPS Gene:100037976 TNFSF11

ENSEMBL:ENSSSCG00000052062.1

KEGG:ssc:100037976 TNFSF11

Monarch:100037976 TNFSF11

NCBI Gene:100037976 TNFSF11

UCSC:F1RJX1 TNFSF11

Reference Transcript

RefSeq:XM_001925694.6 TNFSF11

Other Identifiers

100037976

GO:0000122

GO:0001503

GO:0002158

GO:0002376

GO:0002548

GO:0005125

GO:0005164

GO:0005576

GO:0005615

GO:0005886

GO:0006355

GO:0006955

GO:0007166

GO:0007254

GO:0009887

GO:0010628

GO:0016020

GO:0019221

GO:0019722

GO:0030154

GO:0030316

GO:0032813

GO:0033209

GO:0033598

GO:0034112

GO:0036035

GO:0038001

GO:0042802

GO:0043123

GO:0043410

GO:0043491

GO:0044691

GO:0045453

GO:0045670

GO:0045672

GO:0045780

GO:0045944

GO:0046330

GO:0048018

GO:0048856

GO:0050870

GO:0051466

GO:0051897

GO:0055074

GO:0060348

GO:0060749

GO:0070374

GO:0071812

GO:0098772

GO:1901224

GO:1902533

GO:1990830

GO:2001206

GO:2001238

Participates

as a component of

RANKL trimer [plasma membrane] (Sus scrofa)

Other forms of this molecule

TNFSF11 [extracellular region]

Inferred From

TNFSF11 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_001925729.4

ENSEMBL

ENSSSCT00000094314, ENSSSCG00000052062, ENSSSCP00000078476

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