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TNFSF11 [plasma membrane]
Stable Identifier
R-HSA-5667141
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Tumor necrosis factor ligand superfamily member 11, TNF11_HUMAN, RANKL
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
MARK3 phosphorylates MITF-M on S173 (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
2xRANK binds RANKL,sRANKL trimer:RANK (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
RANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer binds RANK (Homo sapiens)
RANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TRAFs bind RANK:RANKL (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TNFs bind their physiological receptors (Homo sapiens)
TNFSF11 binds TNFRSF11A, B (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TNFSF11,sTNFSF11 trimer:3xTNFRSF11B [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14788 TNFSF11
Gene Names
TNFSF11, OPGL, RANKL, TRANCE
Chain
chain:1-317, chain:140-317
Reference Genes
COSMIC (genes):TNFSF11 TNFSF11
dbSNP Gene:8600 TNFSF11
ENSEMBL:ENSG00000120659 TNFSF11
Participates
as a component of
RANKL trimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
sTNFSF11 [extracellular region]
Inferred To
TNFSF11 [plasma membrane]
(Bos taurus)
TNFSF11 [plasma membrane]
(Canis familiaris)
TNFSF11 [plasma membrane]
(Danio rerio)
TNFSF11 [plasma membrane]
(Gallus gallus)
TNFSF11 [plasma membrane]
(Sus scrofa)
Tnfsf11 [plasma membrane]
(Mus musculus)
Tnfsf11 [plasma membrane]
(Rattus norvegicus)
tnfsf10l4 [plasma membrane]
(Danio rerio)
cd40lg [plasma membrane]
(Danio rerio)
tnfsf11 [plasma membrane]
(Xenopus tropicalis)
Homologues of TNFSF11 [plasma membrane]
(Danio rerio)
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00300 TNFRSF11B
1
TNFRSF11B [plasma membrane]
(R-HSA-5672848)
0.618
3
UniProt:Q9UBS3 DNAJB9
1
DNAJB9 [endoplasmic reticulum membrane]
(R-HSA-381010)
0.527
2
UniProt:P03886 MT-ND1
1
MT-ND1 [mitochondrial inner membrane]
(R-HSA-60551)
0.527
2
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