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TNFSF11 [plasma membrane]
Stable Identifier
R-HSA-5667141
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Tumor necrosis factor ligand superfamily member 11, TNF11_HUMAN, RANKL
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
2xRANK binds RANKL,sRANKL trimer:RANK (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
RANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer binds RANK (Homo sapiens)
RANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TRAFs bind RANK:RANKL (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TNFs bind their physiological receptors (Homo sapiens)
TNFSF11 binds TNFRSF11A, B (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TNFSF11,sTNFSF11 trimer:3xTNFRSF11B [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
3xRANK:RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL,sRANKL trimer [plasma membrane] (Homo sapiens)
RANKL trimer [plasma membrane] (Homo sapiens)
TNFSF11 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14788 TNFSF11
Gene Names
TNFSF11, OPGL, RANKL, TRANCE
Chain
chain:1-317, chain:140-317
Reference Genes
BioGPS Gene:8600 TNFSF11
COSMIC (genes):TNFSF11 TNFSF11
CTD Gene:8600 TNFSF11
dbSNP Gene:8600 TNFSF11
ENSEMBL:ENSG00000120659 TNFSF11
ENSEMBL_homo_sapiens_GENE:ENSG00000120659.16 TNFSF11
HGNC:11926 TNFSF11
KEGG Gene (Homo sapiens):8600 TNFSF11
Monarch:8600 TNFSF11
NCBI Gene:8600 TNFSF11
OMIM:602642 TNFSF11
UCSC:O14788 TNFSF11
Reference Transcript
RefSeq:XM_011535280.2 TNFSF11
RefSeq:NM_003701.3 TNFSF11
RefSeq:XM_017020803.1 TNFSF11
RefSeq:NM_033012.3 TNFSF11
Other Identifiers
11734306_a_at
11734531_a_at
16774384
210643_PM_at
210643_at
211153_PM_s_at
211153_s_at
3487302
3487303
3487305
3487306
3487307
3487308
3487309
3487310
3487312
3487320
3487321
3487322
3487323
3487324
35107_at
7968851
8600
A_14_P126627
A_23_P99386
A_33_P3503029
GE79109
GO:0000122
GO:0001503
GO:0002158
GO:0002376
GO:0002548
GO:0005102
GO:0005125
GO:0005164
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005886
GO:0006351
GO:0006355
GO:0006954
GO:0006955
GO:0007154
GO:0007155
GO:0007249
GO:0007254
GO:0009887
GO:0010628
GO:0016020
GO:0019221
GO:0019722
GO:0023052
GO:0030154
GO:0030316
GO:0032813
GO:0033209
GO:0033598
GO:0034112
GO:0036035
GO:0036211
GO:0038001
GO:0042327
GO:0042802
GO:0043123
GO:0043406
GO:0043491
GO:0044691
GO:0045453
GO:0045670
GO:0045672
GO:0045780
GO:0045944
GO:0046330
GO:0048018
GO:0048856
GO:0048870
GO:0050870
GO:0051091
GO:0051092
GO:0051466
GO:0051897
GO:0055065
GO:0055074
GO:0060348
GO:0060749
GO:0070371
GO:0071812
GO:0071847
GO:0071848
GO:0098772
GO:1902533
GO:1990830
GO:2001206
HMNXSV003021208
ILMN_1658713
ILMN_1673175
ILMN_1695900
PH_hs_0023847
TC13000154.hg
g3057145_3p_at
g6863047_3p_a_at
Participates
as a component of
RANKL trimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
sTNFSF11 [extracellular region]
Inferred To
TNFSF11 [plasma membrane]
(Bos taurus)
TNFSF11 [plasma membrane]
(Canis familiaris)
TNFSF11 [plasma membrane]
(Danio rerio)
TNFSF11 [plasma membrane]
(Gallus gallus)
TNFSF11 [plasma membrane]
(Sus scrofa)
Tnfsf11 [plasma membrane]
(Mus musculus)
Tnfsf11 [plasma membrane]
(Rattus norvegicus)
dl3 [plasma membrane]
(Danio rerio)
tnfsf11 [plasma membrane]
(Xenopus tropicalis)
Homologues of TNFSF11 [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_003692.1
,
NP_143026.1
,
XP_016876292.1
,
XP_011533582.1
OpenTargets
ENSG00000120659
HPA
ENSG00000120659-TNFSF11
GeneCards
O14788
Ensembl
ENST00000398795
,
ENSG00000120659
,
ENST00000358545
,
ENSP00000381775
,
ENSP00000351347
PRO
O14788
Pharos - Targets
O14788
Orphanet
17256
HMDB Protein
HMDBP02409
PDB
3URF
,
5BNQ
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00300 TNFRSF11B
1
TNFRSF11B [plasma membrane]
(R-HSA-5672848)
0.618
3
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