Reactome | SETD1B [nucleoplasm]

SETD1B [nucleoplasm]

Stable Identifier

R-SSC-5244714

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

SETD1B, A0A5G2RGL8

Locations in the PathwayBrowser

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Gene expression (Transcription) (Sus scrofa)

- Epigenetic regulation of gene expression (Sus scrofa)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Sus scrofa)
    - Formation of WDR5-containing histone-modifying complexes (Sus scrofa)
      - CXXC1 and WDR82 bind SET1B complex (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        SET1B complex:WDR82:CXXC1 [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
      - Formation of the SET1B complex (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional regulation by RUNX1 (Sus scrofa)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        SET1B complex [nucleoplasm] (Sus scrofa)
        
        SETD1B [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2RGL8

Gene Names

SETD1B

Reference Genes

ENSEMBL:ENSSSCG00000051618.2

UCSC:A0A5G2RGL8 SETD1B

Other Identifiers

100156137

GO:0003676

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006338

GO:0008168

GO:0016607

GO:0016740

GO:0032259

GO:0035097

GO:0042800

GO:0048188

GO:0140096

Participates

as a member of

SUV39H1, SUV39H2, SETDB1, SETDB2 [nucleoplasm] (Sus scrofa)

as an input of

Formation of the SET1B complex (Sus scrofa)

as a component of

SET1B complex [nucleoplasm] (Sus scrofa)

Inferred From

SETD1B [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCP00000074163, ENSSSCT00000067788, ENSSSCG00000051618

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