Reactome | CASR [plasma membrane]

CASR [plasma membrane]

Stable Identifier

R-SSC-420719

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

CASR, L0HSA9

Locations in the PathwayBrowser

Expand all

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (i) signalling events (Sus scrofa)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        CASR:Ca2+ [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        CASR:Ca2+ [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        CASR:Ca2+ [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        CASR:Ca2+ [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
      - The Ligand:GPCR:Gi complex dissociates (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        CASR:Ca2+ [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        CASR:Ca2+ [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
    - G alpha (q) signalling events (Sus scrofa)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        CASR:Ca2+ [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        CASR:Ca2+ [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        CASR:Ca2+ [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        CASR:Ca2+ [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
      - The Ligand:GPCR:Gq complex dissociates (Sus scrofa)
        
        GPCRs that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        CASR:Ca2+ [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
  - GPCR ligand binding (Sus scrofa)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Sus scrofa)
      - CASR binds CASR agonists (Sus scrofa)
        
        CASR:CASR agonists [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
      - CASR binds Ca2+ (Sus scrofa)
        
        CASR:Ca2+ [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)
        
        Homologues of CASR [plasma membrane] (Sus scrofa)
        
        CASR [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:L0HSA9

Gene Names

CASR

Reference Genes

BioGPS Gene:100520980 CASR

ENSEMBL:ENSSSCG00000011878.5

KEGG Gene (Sus scrofa):100520980 CASR

Monarch:100520980 CASR

NCBI Gene:100520980 CASR

Reference Transcript

RefSeq:NM_001278748.1 CASR

Other Identifiers

100520980

GO:0004930

GO:0005509

GO:0005513

GO:0005886

GO:0006874

GO:0007165

GO:0007186

GO:0010628

GO:0016020

GO:0016597

GO:0023052

GO:0042803

GO:0051924

GO:0055065

GO:0060089

GO:0070509

Participates

as a member of

Homologues of CASR [plasma membrane] (Sus scrofa)

Inferred From

CASR [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001265677.1

OpenTargets

ENSG00000036828

Ensembl

ENSSSCG00000011878, ENSSSCT00000064997, ENSSSCP00000041077

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