Reactome | ADRA2A [plasma membrane]

ADRA2A [plasma membrane]

Stable Identifier

R-SSC-390655

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

ADRA2A, P18871

Locations in the PathwayBrowser

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Hemostasis (Sus scrofa)

- Platelet activation, signaling and aggregation (Sus scrofa)
  - Platelet Aggregation (Plug Formation) (Sus scrofa)
    - Adrenaline signalling through Alpha-2 adrenergic receptor (Sus scrofa)
      - ADRA2A,B,C bind ADR,NAd (Sus scrofa)
        
        ADRA2A,B,C [plasma membrane] (Sus scrofa)
        
        ADRA2A [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C [plasma membrane] (Sus scrofa)
        
        ADRA2A [plasma membrane] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (i) signalling events (Sus scrofa)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C [plasma membrane] (Sus scrofa)
        
        ADRA2A [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C [plasma membrane] (Sus scrofa)
        
        ADRA2A [plasma membrane] (Sus scrofa)
    - G alpha (z) signalling events (Sus scrofa)
      - Liganded Gz-activating GPCR acts as a GEF for Gz (Sus scrofa)
        
        ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C [plasma membrane] (Sus scrofa)
        
        ADRA2A [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C [plasma membrane] (Sus scrofa)
        
        ADRA2A [plasma membrane] (Sus scrofa)
  - GPCR ligand binding (Sus scrofa)
    - Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
      - Amine ligand-binding receptors (Sus scrofa)
        
        Adrenoceptors (Sus scrofa)
        
        ADRA2A,B,C bind ADR,NAd (Sus scrofa)
        
        ADRA2A,B,C [plasma membrane] (Sus scrofa)
        
        ADRA2A [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C:ADR,NAd [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C [plasma membrane] (Sus scrofa)
        
        ADRA2A [plasma membrane] (Sus scrofa)
        
        α2-agonists bind ADRA2A,B,C (Sus scrofa)
        
        ADRA2A,B,C [plasma membrane] (Sus scrofa)
        
        ADRA2A [plasma membrane] (Sus scrofa)
        
        α2-agonists:ADRA2A,B,C [plasma membrane] (Sus scrofa)
        
        ADRA2A,B,C [plasma membrane] (Sus scrofa)
        
        ADRA2A [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:P18871

Gene Names

ADRA2A

Reference Genes

BioGPS Gene:399501 ADRA2A

ENSEMBL:ENSSSCG00000010629

KEGG:ssc:399501 ADRA2A

Monarch:399501 ADRA2A

NCBI Gene:399501 ADRA2A

UCSC:P18871 ADRA2A

Reference Transcript

RefSeq:NM_214400.1 ADRA2A

Other Identifiers

399501

GO:0001819

GO:0003013

GO:0004930

GO:0004935

GO:0004938

GO:0005737

GO:0005886

GO:0006940

GO:0007165

GO:0007173

GO:0007186

GO:0010700

GO:0016020

GO:0019229

GO:0019901

GO:0030168

GO:0030335

GO:0031696

GO:0031996

GO:0032795

GO:0032870

GO:0042593

GO:0042596

GO:0042803

GO:0043235

GO:0043410

GO:0045742

GO:0046676

GO:0046982

GO:0050995

GO:0051044

GO:0051379

GO:0051380

GO:0051897

GO:0061179

GO:0071875

GO:0071880

GO:0071881

GO:0071882

GO:0090303

GO:0098691

GO:0098793

GO:0099171

Ssc.27594.1.S1_at

Participates

as a member of

Inferred From

ADRA2A [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_999565.1

ZINC - World Drugs

ADA2A_PIG

ENSEMBL

ENSSSCT00000011625, ENSSSCP00000011323, ENSSSCG00000010629

ZINC - FDA approved

ADA2A_PIG

ZINC - Substances

ADA2A_PIG

ZINC - Biogenic

ADA2A_PIG

ZINC target

P18871

VGNC

85156

ZINC - Predictions - Purchasable

ADA2A_PIG