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ADRA2A [plasma membrane]
Stable Identifier
R-HSA-390655
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Alpha-2A adrenoceptor, RecName: Full=Alpha-2A adrenergic receptor; AltName: Full=Alpha-2A adrenoreceptor; AltName: Full=Alpha-2A adrenoceptor; Short=Alpha-2AAR; AltName: Full=Alpha-2 adrenergic receptor subtype C10;
GN Name=ADRA2A; Synonyms=ADRA2R, ADRAR;
OS Homo sapiens, ADA2A_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Adrenaline signalling through Alpha-2 adrenergic receptor (Homo sapiens)
ADRA2A,B,C bind ADR,NAd (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Adrenaline,noradrenaline inhibits insulin secretion (Homo sapiens)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Homo sapiens)
ADRA2A,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
ADRA2A,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Surfactant metabolism (Homo sapiens)
SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Homo sapiens)
ADRA2A,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
Liganded Gz-activating GPCR acts as a GEF for Gz (Homo sapiens)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gz complex dissociates (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Adrenoceptors (Homo sapiens)
ADRA2A,B,C bind ADR,NAd (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
α2-agonists bind ADRA2A,B,C (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
α2-agonists:ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08913 ADRA2A
Gene Names
ADRA2A, ADRA2R, ADRAR
Chain
chain:1-465
Reference Genes
BioGPS Gene:150 ADRA2A
COSMIC (genes):ADRA2A ADRA2A
CTD Gene:150 ADRA2A
dbSNP Gene:150 ADRA2A
ENSEMBL:ENSG00000150594 ADRA2A
HGNC:281 ADRA2A
KEGG Gene (Homo sapiens):150 ADRA2A
Monarch:150 ADRA2A
NCBI Gene:150 ADRA2A
OMIM:104210 ADRA2A
UCSC:P08913 ADRA2A
Reference Transcript
RefSeq:NM_000681.3 ADRA2A
Other Identifiers
0003840181
11722112_at
150
16709245
209869_PM_at
209869_at
264_at
3264060
3264061
3264062
3264063
3264064
3264065
3264066
3264067
3264068
3264069
3264070
3264071
3264072
64888_at
7930482
A_14_P135211
A_23_P138706
GE62189
GO:0000003
GO:0001819
GO:0002526
GO:0003013
GO:0003674
GO:0004930
GO:0004935
GO:0004938
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005886
GO:0005887
GO:0006260
GO:0006464
GO:0006629
GO:0006810
GO:0006940
GO:0006950
GO:0007010
GO:0007165
GO:0007186
GO:0007189
GO:0007193
GO:0007265
GO:0007266
GO:0007267
GO:0007565
GO:0008150
GO:0008283
GO:0008284
GO:0009056
GO:0009058
GO:0010700
GO:0015031
GO:0016020
GO:0016021
GO:0016192
GO:0016323
GO:0019229
GO:0019899
GO:0019901
GO:0030036
GO:0030168
GO:0030335
GO:0031692
GO:0031696
GO:0031996
GO:0032147
GO:0032148
GO:0032795
GO:0032811
GO:0032870
GO:0032991
GO:0035624
GO:0040011
GO:0042311
GO:0042592
GO:0042593
GO:0042596
GO:0042803
GO:0043025
GO:0043226
GO:0043235
GO:0043268
GO:0043406
GO:0043410
GO:0043679
GO:0045202
GO:0045741
GO:0045955
GO:0046676
GO:0046982
GO:0048870
GO:0050877
GO:0050892
GO:0050955
GO:0050995
GO:0051044
GO:0051379
GO:0051380
GO:0051926
GO:0055085
GO:0061179
GO:0070473
GO:0071875
GO:0071880
GO:0071881
GO:0071882
GO:0090303
GO:0098691
GO:0098978
GO:0098982
GO:0099055
GO:0099059
GO:0099061
GO:1901020
GO:2000300
HMNXSV003033128
ILMN_1659371
M23533_at
PH_hs_0013209
TC10000811.hg
g13447750_3p_at
Participates
as a member of
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
Inferred To
tyra-2 [plasma membrane]
(Caenorhabditis elegans)
ADRA2A [plasma membrane]
(Bos taurus)
ADRA2A [plasma membrane]
(Canis familiaris)
ADRA2A [plasma membrane]
(Gallus gallus)
ADRA2A [plasma membrane]
(Sus scrofa)
Homologues of ADRA2A [plasma membrane]
(Caenorhabditis elegans)
Homologues of ADRA2A [plasma membrane]
(Drosophila melanogaster)
Oct-TyrR [plasma membrane]
(Drosophila melanogaster)
Octalpha2R [plasma membrane]
(Drosophila melanogaster)
Adra2a [plasma membrane]
(Mus musculus)
Adra2a [plasma membrane]
(Rattus norvegicus)
adra2a [plasma membrane]
(Danio rerio)
adra2a [plasma membrane]
(Xenopus tropicalis)
ser-2 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000672.3
ZINC - World Drugs
ADA2A_HUMAN
Guide to Pharmacology - Targets
25
OpenTargets
ENSG00000150594
ZINC - FDA approved
ADA2A_HUMAN
ZINC - Substances
ADA2A_HUMAN
ZINC target
P08913
ZINC - Biogenic
ADA2A_HUMAN
PRO
P08913
PDB
1HOF
,
6KUY
,
6K42
,
1HO9
,
6KUX
,
1HLL
,
1HOD
ZINC - Investigational
ADA2A_HUMAN
ZINC - Metabolites
ADA2A_HUMAN
HPA
ENSG00000150594-ADRA2A
GeneCards
P08913
Ensembl
ENSP00000280155
,
ENSG00000150594
,
ENST00000280155
Pharos - Targets
P08913
ZINC - Predictions - Purchasable
ADA2A_HUMAN
Orphanet
26398
HMDB Protein
HMDBP01601
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