Reactome | CHD4 [nucleoplasm]

CHD4 [nucleoplasm]

Stable Identifier

R-SSC-3702078

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

CHD4, F1SLR5

Locations in the PathwayBrowser

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Chromatin organization (Sus scrofa)

- Chromatin modifying enzymes (Sus scrofa)
  - HDACs deacetylate histones (Sus scrofa)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Sus scrofa)
      - HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        Mi-2 [nucleoplasm] (Sus scrofa)
        
        CHD4 [nucleoplasm] (Sus scrofa)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Sus scrofa)
        
        HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        Mi-2 [nucleoplasm] (Sus scrofa)
        
        CHD4 [nucleoplasm] (Sus scrofa)
    - HDAC1:2-containing complex deacetylate histones (Sus scrofa)
      - HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        Mi-2 [nucleoplasm] (Sus scrofa)
        
        CHD4 [nucleoplasm] (Sus scrofa)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Sus scrofa)
        
        HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        Mi-2 [nucleoplasm] (Sus scrofa)
        
        CHD4 [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase I Transcription (Sus scrofa)
  - RNA Polymerase I Promoter Clearance (Sus scrofa)
    - RNA Polymerase I Transcription Initiation (Sus scrofa)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Sus scrofa)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        Mi-2 [nucleoplasm] (Sus scrofa)
        
        CHD4 [nucleoplasm] (Sus scrofa)
- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - Regulation of TP53 Activity (Sus scrofa)
        
        Regulation of TP53 Activity through Acetylation (Sus scrofa)
        
        MTA2-NuRD complex deacetylates TP53 (Sus scrofa)
        
        MTA2-NuRD complex [nucleoplasm] (Sus scrofa)
        
        Mi-2 [nucleoplasm] (Sus scrofa)
        
        CHD4 [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - PTEN Regulation (Sus scrofa)
      - Regulation of PTEN gene transcription (Sus scrofa)
        
        SALL4 recruits NuRD to PTEN gene (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        Mi-2 [nucleoplasm] (Sus scrofa)
        
        CHD4 [nucleoplasm] (Sus scrofa)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Sus scrofa)
        
        SALL4:NuRD [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        Mi-2 [nucleoplasm] (Sus scrofa)
        
        CHD4 [nucleoplasm] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by NTRKs (Sus scrofa)
    - Signaling by NTRK1 (TRKA) (Sus scrofa)
      - Nuclear Events (kinase and transcription factor activation) (Sus scrofa)
        
        NGF-stimulated transcription (Sus scrofa)
        
        NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Sus scrofa)
        
        CHD4 [nucleoplasm] (Sus scrofa)
        
        RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Sus scrofa)
        
        CHD4 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1SLR5

Gene Names

CHD4

Reference Genes

ENSEMBL:ENSSSCG00000000697.5

Reference Transcript

RefSeq:XM_013987451.1 CHD4

Other Identifiers

100515610

GO:0000166

GO:0000724

GO:0000781

GO:0001221

GO:0003677

GO:0003714

GO:0003824

GO:0004386

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0006281

GO:0006310

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0010629

GO:0016581

GO:0016787

GO:0016887

GO:0042826

GO:0043226

GO:0045892

GO:0046872

GO:0061629

GO:0090575

GO:0090734

GO:0140097

GO:0140110

GO:0140657

GO:0140658

Ssc.16672.1.S1_at

Ssc.25044.1.S1_at

Ssc.25044.3.A1_a_at

Participates

as a component of

RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Sus scrofa)

as an input of

NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Sus scrofa)

as a member of

Mi-2 [nucleoplasm] (Sus scrofa)

Inferred From

CHD4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_013842905.1

OpenTargets

ENSG00000111642

Ensembl

ENSSSCG00000000697, ENSSSCT00000003736, ENSSSCP00000003650