Reactome | HIST1H3E [nucleoplasm]

HIST1H3E [nucleoplasm]

Stable Identifier

R-SSC-212220

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

Me3K28-HIST1H3A, F1RVA0

Locations in the PathwayBrowser

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Cell-Cell communication (Sus scrofa)

- Cell junction organization (Sus scrofa)
  - Cell-cell junction organization (Sus scrofa)
    - Adherens junctions interactions (Sus scrofa)
      - Regulation of Homotypic Cell-Cell Adhesion (Sus scrofa)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Sus scrofa)
        
        Regulation of CDH1 Expression and Function (Sus scrofa)
        
        Regulation of CDH1 Gene Transcription (Sus scrofa)
        
        Negative Regulation of CDH1 Gene Transcription (Sus scrofa)
        
        PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter (Sus scrofa)
        
        PRC2 (EZH2) Core:H3K27me3-Nucleosome:CDH1 gene [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Sus scrofa)
        
        HIST1H3E [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- Epigenetic regulation of gene expression (Sus scrofa)
  - PRC2 methylates histones and DNA (Sus scrofa)
    - DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Sus scrofa)
      - DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Sus scrofa)
        
        PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Sus scrofa)
        
        Chromatin with hemimethylC, H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Sus scrofa)
        
        HIST1H3E [nucleoplasm] (Sus scrofa)
    - PRC2 trimethylates histone H3 at lysine-27 (Sus scrofa)
      - PRC2:Chromatin (H3K27me3) [nucleoplasm] (Sus scrofa)
        
        Chromatin with trimethylated H3K27 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Sus scrofa)
        
        Histone H3 (H3K27me3) [nucleoplasm] (Sus scrofa)
        
        HIST1H3E [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RVA0

Gene Names

HIST1H3E

Reference Genes

BioGPS Gene:100154511 HIST1H3E

BioGPS Gene:106504121 HIST1H3E

ENSEMBL:ENSSSCG00000059210.1

KEGG:ssc:100154511 HIST1H3E

KEGG:ssc:106504121 HIST1H3E

Monarch:100154511 HIST1H3E

Monarch:106504121 HIST1H3E

NCBI Gene:100154511 HIST1H3E

NCBI Gene:106504121 HIST1H3E

UCSC:F1RVA0 HIST1H3E

Reference Transcript

RefSeq:NM_001287416.1 HIST1H3E

Other Identifiers

100154511

106504121

GO:0000786

GO:0003677

GO:0005198

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006334

GO:0010467

GO:0030527

GO:0032991

GO:0040029

GO:0046982

GO:0065003

Participates

as a candidate of

Me3K28-histone H3 [nucleoplasm] (Sus scrofa)

as a member of

Histone H3 (H3K27me3) [nucleoplasm] (Sus scrofa)

Other forms of this molecule

HIST1H3E [nucleoplasm]

phospho-HIST1H3E [nucleoplasm]

HIST1H3E [nucleoplasm]

HIST1H3E [extracellular region]

HIST1H3E [nucleoplasm]

phospho-HIST1H3E [nucleoplasm]

HIST1H3E [nucleoplasm]

HIST1H3E [cytosol]

Inferred From

Me3K28-HIST1H3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 28 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

NP_001274345.1

ENSEMBL

ENSSSCG00000053072, ENSSSCG00000061876, ENSSSCG00000059210, ENSSSCG00000056496, ENSSSCP00000076483, ENSSSCP00000080631, ENSSSCP00000080899, ENSSSCP00000080830, ENSSSCT00000097116, ENSSSCT00000093227, ENSSSCG00000060961, ENSSSCT00000096945, ENSSSCT00000093155, ENSSSCP00000075397, ENSSSCP00000080818, ENSSSCT00000103518, ENSSSCG00000052704, ENSSSCT00000100037