Reactome | PIK3CA:PIK3R1 [cytosol]

PIK3CA:PIK3R1 [cytosol]

Stable Identifier

R-SSC-1806218

Type

Complex

Species

Sus scrofa

Compartment

cytosol

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

PIK3CA [cytosol] (Sus scrofa)
PIK3R1 [cytosol] (Sus scrofa)

Participates

as a member of

PI3K alpha, gamma [cytosol] (Sus scrofa)
PIK3C(1) [cytosol] (Sus scrofa)
PIK3(2) [cytosol] (Sus scrofa)

as an input of

Phosphorylated GAB1 recruits PI3K to MET (Sus scrofa)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Sus scrofa)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Sus scrofa)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Sus scrofa)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Sus scrofa)

as a component of

HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Sus scrofa)
PI3K:p-ERBB4cyt1 [plasma membrane] (Sus scrofa)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Sus scrofa)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Sus scrofa)

Inferred From

PIK3CA:PIK3R1 [cytosol] (Homo sapiens)