Reactome | RAD9B [nucleoplasm]

RAD9B

Stable Identifier

R-SSC-176325

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

F1RNM9

Locations in the PathwayBrowser

Expand all

Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - G2/M Checkpoints (Sus scrofa)
    - Activation of ATR in response to replication stress (Sus scrofa)
      - Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
    - G2/M DNA damage checkpoint (Sus scrofa)
      - ATR phosphorylates TP53 (Sus scrofa)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)

DNA Repair (Sus scrofa)

- DNA Double-Strand Break Repair (Sus scrofa)
  - Homology Directed Repair (Sus scrofa)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Sus scrofa)
      - HDR through Homologous Recombination (HRR) (Sus scrofa)
        
        Homologous DNA Pairing and Strand Exchange (Sus scrofa)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Sus scrofa)
        
        RAD51 binds BRCA2 at resected DNA DSBs (Sus scrofa)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
      - HDR through Single Strand Annealing (SSA) (Sus scrofa)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Sus scrofa)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Sus scrofa)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        ERCC1:XPF cleaves flaps generated by SSA (Sus scrofa)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Sus scrofa)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
      - Processing of DNA double-strand break ends (Sus scrofa)
        
        ATR activation at DNA DSBs (Sus scrofa)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        ATR phosphorylates RPA2 (Sus scrofa)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        Activation of CHEK1 at resected DNA DSBs (Sus scrofa)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        CHEK1 is recruited to resected DNA DSBs (Sus scrofa)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - Regulation of TP53 Activity (Sus scrofa)
        
        Regulation of TP53 Activity through Phosphorylation (Sus scrofa)
        
        ATR phosphorylates TP53 (Sus scrofa)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Sus scrofa)
        
        RAD9 [nucleoplasm] (Sus scrofa)
        
        Homologues of RAD9B [nucleoplasm] (Sus scrofa)
        
        RAD9B [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RNM9

Reference Genes

BioGPS Gene:100738069

dbSNP Gene:100738069

ENSEMBL:ENSSSCG00000009824

KEGG Gene (Sus scrofa):ssc:100738069

Monarch:100738069

NCBI Gene:100738069

Reference Transcript

RefSeq:XM_005670641.2

Other Identifiers

100738069

AEMK02000096

ENSSSCG00000009824

ENSSSCP00000010487

ENSSSCT00000010767

EntrezGene:100738069

GO:0000075

GO:0000077

GO:0000228

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005694

GO:0006259

GO:0006281

GO:0006950

GO:0007049

GO:0008150

GO:0030896

GO:0032991

GO:0034641

GO:0043226

HGNC:21700

I3L841

IPR007268

IPR026584

PF04139

RAD9B

RAD9B-201

UPI0003AEE193

XM_005670641

XM_013982863

XM_013982864

XP_005670698

XP_013838317

XP_013838318

Participant Of

hasMember

Homologues of RAD9B [nucleoplasm]

Inferred From

RAD9B [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_005670698.1