Reactome | F2 [extracellular region]

F2 [extracellular region]

Stable Identifier

R-SSC-140598

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

F2(315-363), F1SIB1

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Complement cascade (Sus scrofa)
    - Regulation of Complement cascade (Sus scrofa)
      - Thrombin, ELANE cleave C5 (Sus scrofa)
        
        Activated thrombin, (ELANE) [extracellular region] (Sus scrofa)
        
        activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
        
        F2 [extracellular region] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (q) signalling events (Sus scrofa)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Sus scrofa)
        
        activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
        
        F2 [extracellular region] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Sus scrofa)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Sus scrofa)
        
        activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
        
        F2 [extracellular region] (Sus scrofa)
  - GPCR ligand binding (Sus scrofa)
    - Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
      - Peptide ligand-binding receptors (Sus scrofa)
        
        Proteinase-activated receptors can bind thrombin (Sus scrofa)
        
        Thrombin:Proteinase-activated receptors [plasma membrane] (Sus scrofa)
        
        activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
        
        F2 [extracellular region] (Sus scrofa)
        
        activated thrombin (factor IIa) [extracellular region] (Sus scrofa)
        
        F2 [extracellular region] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1SIB1

Gene Names

Reference Genes

ENSEMBL:ENSSSCG00000013252.5

UCSC:F1SIB1 F2

Other Identifiers

100144442

GO:0001530

GO:0002376

GO:0004175

GO:0004252

GO:0005102

GO:0005509

GO:0005576

GO:0005615

GO:0006508

GO:0006953

GO:0006954

GO:0007166

GO:0007186

GO:0007596

GO:0007599

GO:0008201

GO:0008233

GO:0008236

GO:0008284

GO:0008289

GO:0008360

GO:0009611

GO:0009897

GO:0010468

GO:0016787

GO:0030168

GO:0030194

GO:0030195

GO:0030307

GO:0032024

GO:0032967

GO:0042730

GO:0045861

GO:0048018

GO:0048712

GO:0051281

GO:0051480

GO:0051604

GO:0051838

GO:0051897

GO:0061844

GO:0070053

GO:0070493

GO:0070945

GO:0072378

GO:0098542

GO:0098772

GO:1900016

GO:1900182

GO:1900738

GO:1990806

GO:2000379

Ssc.15302.1.S1_at

Participates

as a component of

activated thrombin (factor IIa) [extracellular region] (Sus scrofa)

Other forms of this molecule

F2 [Golgi lumen]

F2 [endoplasmic reticulum lumen]

F2 [plasma membrane]

F2 [extracellular region]

Inferred From

F2(315-363) [extracellular region] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCP00000014081, ENSSSCT00000014473, ENSSSCG00000013252

VGNC

97993

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