Reactome | CREBBP,EP300 [nucleoplasm]

Cellular responses to stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular response to chemical stress (Sus scrofa)
    - KEAP1-NFE2L2 pathway (Sus scrofa)
      - Nuclear events mediated by NFE2L2 (Sus scrofa)
        
        CREBBP, EP300 acetylates NFE2L2 (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm] (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        p-NFE2L2:CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        NFE2L2 binds CREBBP,EP300 (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        p-NFE2L2:CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
  - Cellular response to heat stress (Sus scrofa)
    - HSF1-dependent transactivation (Sus scrofa)
      - Attenuation phase (Sus scrofa)
        
        HSF1 acetylation at Lys80 (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)

Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - C-type lectin receptors (CLRs) (Sus scrofa)
    - CD209 (DC-SIGN) signaling (Sus scrofa)
      - CBP and p300 binds NF-kB complex (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        NFKB1:p-S276-RELA:p300/CBP [nucleoplasm] (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
      - p300 acetylates RELA subunit (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        NFKB1:p-S276,5AcK-RELA:p300/CBP [nucleoplasm] (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        NFKB1:p-S276-RELA:p300/CBP [nucleoplasm] (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
  - Cytosolic sensors of pathogen-associated DNA (Sus scrofa)
    - LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (Sus scrofa)
      - Beta-catenin enhances association of IRF3 with CBP/p300 (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        beta-catenin:IRF3:p300 [nucleoplasm] (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Sus scrofa)
    - TRAF6 mediated IRF7 activation (Sus scrofa)
      - Formation of VAF (virus-activated factor) complex (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        VAF (virus-activated factor) [nucleoplasm] (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
      - p-IRF7 dimer interacts with coactivator CBP/p300 (Sus scrofa)
        
        CBP/p300:pIRF7:pIRF7 [nucleoplasm] (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by WNT (Sus scrofa)
  - TCF dependent signaling in response to WNT (Sus scrofa)
    - Formation of the beta-catenin:TCF transactivating complex (Sus scrofa)
      - Beta-catenin recruits CBP/p300 (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)
        
        TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] (Sus scrofa)
        
        CREBBP,EP300 [nucleoplasm] (Sus scrofa)