Reactome | NMD2 [cytosol]

NMD2 [cytosol]

Stable Identifier

R-SCE-927799

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

UPF2, P38798

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)
        
        NMD2 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)
        
        NMD2 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)
        
        NMD2 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P38798

Gene Names

NMD2

Reference Genes

BioGPS Gene:856476 NMD2

ENSEMBL:YHR077C

KEGG:sce:YHR077C NMD2

Monarch:856476 NMD2

NCBI Gene:856476 NMD2

SGD:YHR077C

UCSC:P38798 NMD2

Reference Transcript

RefSeq:NM_001179207.1 NMD2

Other Identifiers

856476

GO:0000184

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005737

GO:0005844

GO:0006310

GO:0006401

GO:0035145

GO:0070478

GO:0071026

Participates

as a component of

Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)

Inferred From

UPF2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_011944.2

ENSEMBL

YHR077C_mRNA, YHR077C, YHR077C

PRO

P38798

PDB

4LUN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30771	2	phospho-p-4S-UPF1 [cytosol] (R-SCE-927856) UPF1 [cytosol] (R-SCE-927734)	0.547	2

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