Reactome | VMA8 [cytosol]

VMA8 [cytosol]

Stable Identifier

R-SCE-912597

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

ATP6V1D, P32610

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Cellular response to starvation (Saccharomyces cerevisiae)
    - Amino acids regulate mTORC1 (Saccharomyces cerevisiae)
      - RRAGA,B hydrolyzes GTP (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        VMA8 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        VMA8 [cytosol] (Saccharomyces cerevisiae)
      - RRAGC,D exchanges GTP for GDP (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        VMA8 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        VMA8 [cytosol] (Saccharomyces cerevisiae)
      - RRAGC,D hydrolyzes GTP (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        VMA8 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        VMA8 [cytosol] (Saccharomyces cerevisiae)
      - mTORC1 binds RHEB:GTP (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        VMA8 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        VMA8 [cytosol] (Saccharomyces cerevisiae)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        VMA8 [cytosol] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase:Ragulator [lysosomal membrane] (Saccharomyces cerevisiae)
        
        v-ATPase [lysosomal membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        VMA8 [cytosol] (Saccharomyces cerevisiae)

Signal Transduction (Saccharomyces cerevisiae)

- Signaling by Receptor Tyrosine Kinases (Saccharomyces cerevisiae)
  - Signaling by Insulin receptor (Saccharomyces cerevisiae)
    - Insulin receptor recycling (Saccharomyces cerevisiae)
      - Endosome acidification (Saccharomyces cerevisiae)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Saccharomyces cerevisiae)
        
        V-ATPase [endosome membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        VMA8 [cytosol] (Saccharomyces cerevisiae)

Transport of small molecules (Saccharomyces cerevisiae)

- Iron uptake and transport (Saccharomyces cerevisiae)
  - Transferrin endocytosis and recycling (Saccharomyces cerevisiae)
    - Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)
      - V-ATPase:ATP6AP1 [endosome membrane] (Saccharomyces cerevisiae)
        
        V-ATPase [endosome membrane] (Saccharomyces cerevisiae)
        
        ATP6V1 [cytosol] (Saccharomyces cerevisiae)
        
        VMA8 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P32610

Gene Names

VMA8

Reference Genes

BioGPS Gene:856659 VMA8

ENSEMBL:YEL051W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YEL051W VMA8

Monarch:856659 VMA8

NCBI Gene:856659 VMA8

SGD:YEL051W

Reference Transcript

RefSeq:NM_001178866.1 VMA8

Other Identifiers

1770014_at

5784_at

856659

GO:0000221

GO:0000329

GO:0003674

GO:0005575

GO:0005737

GO:0005773

GO:0005794

GO:0005886

GO:0006873

GO:0007035

GO:0008150

GO:0012505

GO:0016020

GO:0022857

GO:0042626

GO:0046961

Participates

as a component of

ATP6V1 [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

VMA8 [plasma membrane]

VMA8 [specific granule membrane]

Inferred From

ATP6V1D [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_010863.1

PRO

P32610

PDB

3J9T, 5VOY, 6O7V, 5VOX, 3J9U, 5VOZ, 6O7W, 6O7X, 5BW9, 4RND, 5D80, 3J9V

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96EV8 DTNBP1	1	DTNBP1 [cytosol] (R-HSA-429819)	0.61	4
UniProt:P38929	4	PMC1 [plasma membrane] (R-SCE-418301) PMC1 [plasma membrane] (R-SCE-418300) PMC1 [plasma membrane] (R-SCE-418303) PMC1 [plasma membrane] (R-SCE-418304)	0.553	2

Cite Us!