Reactome | GSPT1 [cytosol]

GSPT1 [cytosol]

Stable Identifier

R-SCE-8865759

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P05453

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        eRF3:GDP [cytosol] (Saccharomyces cerevisiae)
        
        eRF3 [cytosol] (Saccharomyces cerevisiae)
        
        GSPT1 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        eRF3:GDP [cytosol] (Saccharomyces cerevisiae)
        
        eRF3 [cytosol] (Saccharomyces cerevisiae)
        
        GSPT1 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        eRF3:GDP [cytosol] (Saccharomyces cerevisiae)
        
        eRF3 [cytosol] (Saccharomyces cerevisiae)
        
        GSPT1 [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        eRF3:GDP [cytosol] (Saccharomyces cerevisiae)
        
        eRF3 [cytosol] (Saccharomyces cerevisiae)
        
        GSPT1 [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        eRF3:GDP [cytosol] (Saccharomyces cerevisiae)
        
        eRF3 [cytosol] (Saccharomyces cerevisiae)
        
        GSPT1 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P05453 SUP35

Gene Names

SUP35, GST1, PNM2, SAL3, SUF12, SUP2, YDR172W, YD9395.05

Chain

initiator methionine:, chain:2-685

Reference Genes

BioGPS Gene:851752 SUP35

Monarch:851752 SUP35

NCBI Gene:851752 SUP35

UCSC:P05453 SUP35

Reference Transcript

RefSeq:NM_001180479.3 SUP35

Other Identifiers

1774265_at

6318_at

851752

GO:0000166

GO:0000288

GO:0002181

GO:0002184

GO:0003674

GO:0003723

GO:0003729

GO:0003747

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005737

GO:0005773

GO:0005829

GO:0006401

GO:0006412

GO:0006415

GO:0006417

GO:0008135

GO:0008150

GO:0010494

GO:0016787

GO:0018444

GO:0042802

GO:0043167

Participates

as a member of

eRF3 [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

eRF3 [cytosol]

GSPT2 [cytosol]

Inferred From

GSPT1 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

YDR172W_mRNA, YDR172W

PRO

P05453

PDB

5K2H, 4CRN, 5K2F, 5K2G, 5K2E, 1YJO, 1YJP, 2OMM

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12385 SUP45	4	Erf-1 [cytosol] (R-SCE-141665) SUP45 [cytosol] (R-SCE-6800157) SUP45 [cytosol] (R-SCE-9629948) SUP45 [cytosol] (R-SCE-54433)	0.884	38
UniProt:Q12315	1	GLE1 [nucleoplasm] (R-SCE-8932905)	0.524	2