Reactome | RPN9 [cytosol]

RPN9 [cytosol]

Stable Identifier

R-SCE-68794

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

PSMD13, Q04062

Locations in the PathwayBrowser

Expand all

Immune System (Saccharomyces cerevisiae)

- Adaptive Immune System (Saccharomyces cerevisiae)
  - Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
    - Antigen processing-Cross presentation (Saccharomyces cerevisiae)
      - Cross-presentation of soluble exogenous antigens (endosomes) (Saccharomyces cerevisiae)
        
        Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN9 [cytosol] (Saccharomyces cerevisiae)
- Cytokine Signaling in Immune system (Saccharomyces cerevisiae)
  - TNFR2 non-canonical NF-kB pathway (Saccharomyces cerevisiae)
    - 26Sproteasome degrades K48polyUb-NIK (Saccharomyces cerevisiae)
      - 26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN9 [cytosol] (Saccharomyces cerevisiae)

Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - Deubiquitination (Saccharomyces cerevisiae)
    - Ub-specific processing proteases (Saccharomyces cerevisiae)
      - ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN9 [cytosol] (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome:USP14 [cytosol] (Saccharomyces cerevisiae)
        
        ADRM1:26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        26S proteasome [cytosol] (Saccharomyces cerevisiae)
        
        19S regulatory particle [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN9 [cytosol] (Saccharomyces cerevisiae)
  - Proteasome assembly (Saccharomyces cerevisiae)
    - Formation of the 19S regulatory particle lid (Saccharomyces cerevisiae)
      - 19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN9 [cytosol] (Saccharomyces cerevisiae)
      - 19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN9 [cytosol] (Saccharomyces cerevisiae)
    - Formation of the 19S regulatory particle precursor (Saccharomyces cerevisiae)
      - 19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN9 [cytosol] (Saccharomyces cerevisiae)
      - 19S RP precursor [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid [cytosol] (Saccharomyces cerevisiae)
        
        19S RP lid particle 2 [cytosol] (Saccharomyces cerevisiae)
        
        19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN9 [cytosol] (Saccharomyces cerevisiae)
    - Formation of the complex of PSMD7, PSMD12, PSMD13, and PSMD14 (Saccharomyces cerevisiae)
      - PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN9 [cytosol] (Saccharomyces cerevisiae)
      - RPN9 [cytosol] (Saccharomyces cerevisiae)
    - PSMD11 binds PSMD7:PSMD12:PSMD13:PSMD14 (Saccharomyces cerevisiae)
      - 19S RP Lid Module 1 [cytosol] (Saccharomyces cerevisiae)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN9 [cytosol] (Saccharomyces cerevisiae)
      - PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)
        
        RPN9 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:Q04062

Gene Names

RPN9

Reference Genes

BioGPS Gene:852037 RPN9

ENSEMBL:YDR427W

KEGG:sce:YDR427W RPN9

Monarch:852037 RPN9

NCBI Gene:852037 RPN9

SGD:YDR427W

UCSC:Q04062 RPN9

Reference Transcript

RefSeq:NM_001180735.3 RPN9

Other Identifiers

852037

GO:0000502

GO:0005198

GO:0005515

GO:0005575

GO:0005634

GO:0005829

GO:0006511

GO:0008541

GO:0034515

GO:0043161

GO:0043248

GO:0051603

Participates

as an input of

Formation of the complex of PSMD7, PSMD12, PSMD13, and PSMD14 (Saccharomyces cerevisiae)

as a component of

PSMD7:PSMD12:PSMD13:PSMD14 [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

RPN9 [ficolin-1-rich granule lumen]

RPN9 [extracellular region]

RPN9 [secretory granule lumen]

Inferred From

PSMD13 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_010715.3

ENSEMBL

YDR427W_mRNA, YDR427W, YDR427W

PRO

Q04062

PDB

5WVK, 5WVI, 4CR2, 7QO5, 6J2X, 6J2Q, 4CR4, 7QO6, 6J2C, 6J30, 6J2N, 5MPC, 5MPB, 3JCO, 3JCP, 3J47, 4CR3, 5MPD, 5MPE, 7QO3, 3JCK, 2MRI, 5A5B, 2MQW, 6FVY, 2MR3, 6FVX, 6FVU, 9CGC, 6FVT, 6FVV, 6FVW

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12250	4	RPN5 [cytosol] (R-SCE-68792) RPN5 [ficolin-1-rich granule lumen] (R-SCE-6800416) RPN5 [extracellular region] (R-SCE-6806480) RPN5 [secretory granule lumen] (R-SCE-6800934)	0.91	23
UniProt:Q08723	4	RPN8 [cytosol] (R-SCE-68806) RPN8 [ficolin-1-rich granule lumen] (R-SCE-6800406) RPN8 [extracellular region] (R-SCE-6806488) RPN8 [secretory granule lumen] (R-SCE-6801008)	0.863	16
UniProt:P43588	4	PSMD14 [cytosol] (R-SCE-68722) PSMD14 [ficolin-1-rich granule lumen] (R-SCE-6800419) PSMD14 [extracellular region] (R-SCE-6806511) PSMD14 [secretory granule lumen] (R-SCE-6800926)	0.861	13
UniProt:Q12377	4	RPN6 [cytosol] (R-SCE-68790) RPN6 [ficolin-1-rich granule lumen] (R-SCE-6800436) RPN6 [extracellular region] (R-SCE-6806441) RPN6 [secretory granule lumen] (R-SCE-6800943)	0.818	22
UniProt:P38764	4	RPN1 [cytosol] (R-SCE-68796) RPN1 [ficolin-1-rich granule lumen] (R-SCE-6800435) RPN1 [extracellular region] (R-SCE-6806479) RPN1 [secretory granule lumen] (R-SCE-6800919)	0.813	20
UniProt:P38886	1	RPN10 [cytosol] (R-SCE-68800)	0.813	12
UniProt:P33298	1	PSMC4 [cytosol] (R-SCE-68777)	0.809	10
UniProt:P50086	1	NAS6 [cytosol] (R-SCE-3640824-3)	0.784	7
UniProt:P43593	1	UBP6 [cytosol] (R-SCE-5689541)	0.758	17
UniProt:P38348 HSM3			0.758	4
UniProt:Q01939	2	PSMC5 [cytosol] (R-SCE-68780) PSMC5 [nucleoplasm] (R-SCE-174312)	0.758	14
UniProt:P40016	4	RPN3 [cytosol] (R-SCE-68798) RPN3 [ficolin-1-rich granule lumen] (R-SCE-6800408) RPN3 [extracellular region] (R-SCE-6806443) RPN3 [secretory granule lumen] (R-SCE-6800873)	0.758	12
UniProt:P53549	1	PSMC6 [cytosol] (R-SCE-68783)	0.745	7
UniProt:Q06103	4	RPN7 [cytosol] (R-SCE-68804) RPN7 [ficolin-1-rich granule lumen] (R-SCE-6800440) RPN7 [extracellular region] (R-SCE-6806486) RPN7 [secretory granule lumen] (R-SCE-6801036)	0.744	13
UniProt:P53196 RPN14			0.708	4
UniProt:P40327	1	PSMC1 [cytosol] (R-SCE-68768)	0.669	7
UniProt:P33299	4	PSMC2 [cytosol] (R-SCE-68771) PSMC2 [ficolin-1-rich granule lumen] (R-SCE-6800421) PSMC2 [extracellular region] (R-SCE-6806472) PSMC2 [secretory granule lumen] (R-SCE-6800994)	0.669	8
UniProt:P33297	4	PSMC3 [cytosol] (R-SCE-68774) PSMC3 [ficolin-1-rich granule lumen] (R-SCE-6800429) PSMC3 [extracellular region] (R-SCE-6806496) PSMC3 [secretory granule lumen] (R-SCE-6800917)	0.669	7
UniProt:P32628	2	RAD23 [nucleoplasm] (R-SCE-62590) RAD23 [nucleoplasm] (R-SCE-5688076)	0.669	5
UniProt:P32565	3	RPN2 [cytosol] (R-SCE-68786) RPN2 [azurophil granule lumen] (R-SCE-6798741) RPN2 [extracellular region] (R-SCE-6806194)	0.669	13
UniProt:O13563 RPN13			0.669	6
UniProt:P32496	1	RPN12 [cytosol] (R-SCE-68808)	0.669	8
UniProt:P38737 ECM29			0.643	4
UniProt:O94742 SEM1			0.564	15
UniProt:P08566 ARO1			0.527	2
UniProt:P11484	20	HSPA8 [cytosol] (R-SCE-264476-4) HSPA1L [cytosol] (R-SCE-3371410-4) HSPA2 [cytosol] (R-SCE-3371408-4) HSPA8 [nucleoplasm] (R-SCE-5082380-4) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-4) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-4) HSPA6 [extracellular region] (R-SCE-6806500-4) HSPA8 [extracellular region] (R-SCE-6805936-4) HSPA8 [secretory granule lumen] (R-SCE-6801530-4) HSPA6 [secretory granule lumen] (R-SCE-6801472-4) HSPA2 [nucleoplasm] (R-SCE-912480-4) HSPA1L [nucleoplasm] (R-SCE-5082367-4) HSPA14 [nucleoplasm] (R-SCE-5252082-4) HSPA6 [nucleoplasm] (R-SCE-5252088-4) HSPA13 [nucleoplasm] (R-SCE-5252009-4) HSPA7 [nucleoplasm] (R-SCE-5252047-4) HSPA14 [cytosol] (R-SCE-5251948-4) HSPA13 [cytosol] (R-SCE-5251981-4) HSPA6 [cytosol] (R-SCE-3371521-4) HSPA7 [cytosol] (R-SCE-5251954-4)	0.527	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476-3) SSA2 [nucleoplasm] (R-SCE-6792605) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602) SSA2 [nucleoplasm] (R-SCE-5082380-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494-3) SSA2 [extracellular region] (R-SCE-6805872) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936-3) SSA2 [secretory granule lumen] (R-SCE-6801530-3) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [nucleoplasm] (R-SCE-5252047-3)	0.527	2
UniProt:P40303	1	PRE6 [cytosol] (R-SCE-68736)	0.527	2
UniProt:P40302	1	PRE5 [cytosol] (R-SCE-68724)	0.527	2
UniProt:P43583 BLM10			0.508	2

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