TRM12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)

Stable Identifier
R-SCE-6783410
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
cytoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TRM12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)
TRM12 transfers an aminocarboxypropyl group from S-adenosymethionine to yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe), yielding yW-86 (7-((3S)-3-amino-3-carboxypropyl)-4-demethylwyosine) and S-methyl-5'-thioadenosine (Noma et al. 2006, Noma and Suzuki 2006).
Literature References
PubMed ID Title Journal Year
17150819 Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis

Suzuki, T, Noma, A

Nucleic Acids Symp Ser (Oxf) 2006
16642040 Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA

Suzuki, T, Noma, A, Ikeuchi, Y, Kirino, Y

EMBO J. 2006
Participants
Input
Output
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

transferase activity, transferring alkyl or aryl (other than methyl) groups of TRM12 [cytoplasm]

Physical Entity
TRM12 [cytoplasm] (Saccharomyces cerevisiae)
Activity
transferase activity, transferring alkyl or aryl (other than methyl) groups (GO:0016765)
Orthologous Events
TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe) (Homo sapiens)
Authored
May, B  (2015-06-13)
Reviewed
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-15)
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