Reactome | Srsf2 [nucleoplasm]

Srsf2 [nucleoplasm]

Stable Identifier

R-RNO-9770135-2

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

SRSF8, Q6PDU1

Locations in the PathwayBrowser

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Metabolism of RNA (Rattus norvegicus)

- Processing of Capped Intron-Containing Pre-mRNA (Rattus norvegicus)
  - Formation of pre-mRNPs (Rattus norvegicus)
    - Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
      - nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
      - Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
  - mRNA 3'-end processing (Rattus norvegicus)
    - mRNA Polyadenylation (Rattus norvegicus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - Core CPA complex binds capped pre-mRNA (Rattus norvegicus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - PP1 dephosphorylates RNA Pol II (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - RBBP6 activates CPSF complex (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
  - mRNA Splicing (Rattus norvegicus)
    - mRNA Splicing - Major Pathway (Rattus norvegicus)
      - Formation of the Spliceosomal B* complex (Rattus norvegicus)
        
        Spliceosomal B* complex [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal Bact complex [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - Formation of the Spliceosomal C complex containing intron lariat (Rattus norvegicus)
        
        Spliceosomal B* complex [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal C complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - Formation of the Spliceosomal C* complex (Rattus norvegicus)
        
        Spliceosomal C complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal C* complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - Formation of the Spliceosomal P complex and exon ligation (Rattus norvegicus)
        
        Spliceosomal C* complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal P complex [nucleoplasm] (Rattus norvegicus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Rattus norvegicus)
        
        Spliceosomal P complex [nucleoplasm] (Rattus norvegicus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        nonshuttling SRSFs [nucleoplasm] (Rattus norvegicus)
        
        Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)
        
        Srsf2 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q6PDU1

Gene Names

Srsf2

Reference Genes

BioGPS Gene:494445 Srsf2

ENSEMBL:ENSRNOG00000000248

ENSEMBL:ENSRNOG00055031602

ENSEMBL:ENSRNOG00060023483

ENSEMBL:ENSRNOG00065004914

KEGG:rno:494445 Srsf2

Monarch:494445 Srsf2

NCBI Gene:494445 Srsf2

UCSC:Q6PDU1 Srsf2

Reference Transcript

Other Identifiers

10749361

1371839_at

17663673

494445

5787544

5816057

5831581

5983078

6041139

6179114

6233085

6730007

A_64_P015946

GO:0000381

GO:0003676

GO:0003723

GO:0005634

GO:0005681

GO:0016607

GO:0036002

Participates

as a member of

Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)

Other forms of this molecule

Srsf2 [nucleoplasm]

Inferred From

SRSF8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_006247875.1, XP_008766604.1, NP_001009720.1

ENSEMBL

ENSRNOP00000059012, ENSRNOG00000000248, ENSRNOT00000067739

PRO

Q6PDU1

RGD

1359422

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