Reactome | SRSF8 [nucleoplasm]

SRSF8 [nucleoplasm]

Stable Identifier

R-HSA-9770135

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Serine/arginine-rich splicing factor 8, SRSF8_HUMAN

Locations in the PathwayBrowser

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Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Formation of pre-mRNPs (Homo sapiens)
    - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
      - nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
      - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
  - mRNA 3'-end processing (Homo sapiens)
    - mRNA Polyadenylation (Homo sapiens)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - CPSF3 cleaves pre-mRNA at distal 3'UTR PAS (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - Core CPA complex binds capped pre-mRNA (Homo sapiens)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Homo sapiens)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - PP1 dephosphorylates RNA Pol II (Homo sapiens)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - RBBP6 activates CPSF complex (Homo sapiens)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Homo sapiens)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal A complex (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B* complex (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Bact complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C* complex (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal E complex (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Pre-B complex (Homo sapiens)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BRL6 SRSF8

Gene Names

SRSF8, SFRS2B, SRP46

Chain

initiator methionine:1, chain:2-282

Reference Genes

BioGPS Gene:10929 SRSF8

COSMIC (genes):SRSF8 SRSF8

CTD Gene:10929 SRSF8

dbSNP Gene:10929 SRSF8

ENSEMBL:ENSG00000263465 SRSF8

HGNC:16988 SRSF8

KEGG:hsa:10929 SRSF8

Monarch:10929 SRSF8

NCBI Gene:10929 SRSF8

OMIM:603269 SRSF8

UCSC:Q9BRL6 SRSF8

Reference Transcript

Participates

as a member of

nonshuttling SRSFs [nucleoplasm] (Homo sapiens)

Inferred To

Srsf2 [nucleoplasm] (Mus musculus)

Srsf2 [nucleoplasm] (Rattus norvegicus)

Homologues of SRSF8 [nucleoplasm] (Bos taurus)

Homologues of SRSF8 [nucleoplasm] (Danio rerio)

Homologues of SRSF8 [nucleoplasm] (Drosophila melanogaster)

Homologues of SRSF8 [nucleoplasm] (Mus musculus)

Homologues of SRSF8 [nucleoplasm] (Rattus norvegicus)

Homologues of SRSF8 [nucleoplasm] (Sus scrofa)

srsf2a [nucleoplasm] (Danio rerio)

SC35 [nucleoplasm] (Drosophila melanogaster)

Srsf19 [nucleoplasm] (Mus musculus)

Srsf19 [nucleoplasm] (Rattus norvegicus)

maca [nucleoplasm] (Drosophila melanogaster)

SRSF8 [nucleoplasm] (Bos taurus)

SRSF8 [nucleoplasm] (Sus scrofa)

SRSF2 [nucleoplasm] (Bos taurus)

SRSF2 [nucleoplasm] (Gallus gallus)

SRSF2 [nucleoplasm] (Sus scrofa)

rsp-4 [nucleoplasm] (Caenorhabditis elegans)

srsf2b [nucleoplasm] (Danio rerio)

Cross References

RefSeq

XP_016872631.1, NP_115285.1

ENSEMBL

ENSG00000263465, ENSP00000480140, ENST00000587424

OpenTargets

ENSG00000263465

GeneCards

SRSF8

HPA

ENSG00000263465-SRSF8

PRO

Q9BRL6

Pharos - Targets

Q9BRL6

GlyGen

Q9BRL6

PDB

2DNM

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	2

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