Npas4 stimulates Syt10 gene expression

Stable Identifier
R-RNO-9770074
Type
Reaction [omitted]
Species
Rattus norvegicus
Compartment
nucleoplasm, synaptic vesicle membrane
ReviewStatus
5/5
General
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Npas4 stimulates Syt10 gene expression
In rat primary neurons, Npas4 directly activates Syt10 gene transcription (Woitecki et al. 2016). The Syt10 gene encodes Synaptotagmin-10, a Ca2+ sensor required for Ca2+-dependent exocytosis of secretory vesicles in neurons. Syt10 was identified as one of the core activity-regulated inhibitors of death (AID) genes, that exhibit neuroprotective effect by preventing excitotoxicity-induced neuronal cell death (Woitecki et al. 2016).
Literature References
PubMed ID Title Journal Year
26936998 Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration

Müller, JA, van Loo, KM, Woitecki, AM, Sowade, RF, Schoch, S, Becker, AJ

J Neurosci 2016
Participants
Input
Output
This event is regulated
Positively by
Regulator
(Npas4:Arnt,Npas4:Arnt2,Npas4:Arntl):Syt10 gene [nucleoplasm] (Rattus norvegicus)
Active Unit
(Npas4:Arnt,Npas4:Arnt2,Npas4:Arntl) [nucleoplasm]
Orthologous Events
NPAS4 stimulates SYT10 gene expression (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-24)
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