NPAS4 stimulates SYT10 gene expression

Stable Identifier
R-HSA-9769249
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, synaptic vesicle membrane
ReviewStatus
5/5
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NPAS4 stimulates SYT10 gene expression
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Based on studies in rat primary neurons, NPAS4 directly activates SYT10 gene transcription (Woitecki et al. 2016, Brigidi et al. 2019). The SYT10 gene encodes Synaptotagmin-10, a Ca2+ sensor required for Ca2+-dependent exocytosis of secretory vesicles in neurons. SYT10 was identified as one of the core activity-regulated inhibitors of death (AID) genes, that exhibit neuroprotective effect by preventing excitotoxicity-induced neuronal cell death (Woitecki et al. 2016).
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Output
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as an event of
This event is regulated
Positively by
Regulator
(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2):SYT10 gene [nucleoplasm] (Homo sapiens)
Active Unit
(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2) [nucleoplasm]
Inferred From
Npas4 stimulates Syt10 gene expression (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-16)
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