Npas4 translocates to the nucleus

Stable Identifier
R-RNO-9769759
Type
Reaction [omitted]
Species
Rattus norvegicus
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Npas4 translocates to the nucleus
Rat Npas4, which is 93% identical to human Npas4 with respect to amino acid sequence, possesses an overlapping nuclear localization signal (NLS) and a nuclear export signal (NES) in its basic-helix-loop-helix (bHLH) domain, two putative NLSs and one NES in its PAS-2 domain, and two active NESs that overlap with a putative NLS in its C-terminus. The predominant nuclear localization of NPAS4 is especially favored under high-glucose conditions in cell lines (Greb-Markiewicz et al. 2018).
Literature References
PubMed ID Title Journal Year
29899116 Multiple sequences orchestrate subcellular trafficking of neuronal PAS domain-containing protein 4 (NPAS4)

Greb-Markiewicz, B, Zarębski, M, Ożyhar, A

J Biol Chem 2018
Participants
Input
Output
This event is regulated
Positively by
Regulator
alpha-glucose-1,6-bisphosphate [cytoplasm]
Orthologous Events
NPAS4 translocates to the nucleus (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-22)
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