Protonated weak acid translocates across the plasma membrane

Stable Identifier
R-RNO-9749957
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Protonated weak acid translocates across the plasma membrane
Protonated weak acids such as acetic acid and citric acid are uncharged and are therefore able to diffuse across lipid membranes according to the concentration gradient. Passive diffusion of weak acids into type III taste cells contributes to sour taste (Lyall et al. 1997, Lyall et al. 2001).
Literature References
PubMed ID Title Journal Year
11502578 Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction

Lyall, V, Alam, RI, Phan, DQ, Ereso, GL, Phan, TH, Malik, SA, Montrose, MH, Chu, S, Heck, GL, Feldman, GM, DeSimone, JA

Am J Physiol Cell Physiol 2001
9316422 Effects of extracellular pH, PCO2, and HCO3- on intracellular pH in isolated rat taste buds

Lyall, V, Feldman, GM, Heck, GL, DeSimone, JA

Am J Physiol 1997
Participants
Input
Output
Orthologous Events
Protonated weak acid translocates across the plasma membrane (Homo sapiens)
Authored
May, B  (2021-08-09)
Reviewed
Jiang, P  (2021-08-11)
Created
May, B  (2021-08-09)
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