Protonated weak acid translocates across the plasma membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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Protonated weak acids such as acetic acid and citric acid are uncharged and are therefore able to diffuse across lipid membranes according to the concentration gradient (Wolosin and Ginsburg 1975, Walter et al. 1982, Walter and Gutknecht 1984, Xiang and Anderson 1998, Grime et al. 2008, Li et al. 2011, Hannesschlaeger et al. 2019). Passive diffusion of weak acids into type III taste cells contributes to sour taste (inferred from rat taste cells).

Literature References
PubMed ID Title Journal Year
7097246 Weak acid permeability through lipid bilayer membranes. Role of chemical reactions in the unstirred layer

Walter, A, Hastings, D, Gutknecht, J

J Gen Physiol 1982
6699907 Monocarboxylic acid permeation through lipid bilayer membranes

Walter, A, Gutknecht, J

J Membr Biol 1984
237547 The permeation of organic acids through lecithin bilayers. Resemblance to diffusion in polymers

Wolosin, JM, Ginsburg, H

Biochim Biophys Acta 1975
30781892 The Effect of Buffers on Weak Acid Uptake by Vesicles

Hannesschlaeger, C, Pechova, H, Pohl, P, Barta, T

Biomolecules 2019
9826590 Influence of chain ordering on the selectivity of dipalmitoylphosphatidylcholine bilayer membranes for permeant size and shape

Xiang, TX, Anderson, BD

Biophys J 1998
18787114 Quantitative visualization of passive transport across bilayer lipid membranes

Edwards, MA, Rudd, NC, Grime, JM, Unwin, PR

Proc Natl Acad Sci U S A 2008
21806938 Imaging molecular transport across lipid bilayers

Li, S, Hu, PC, Malmstadt, N

Biophys J 2011
Inferred From
Cross References
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