Reactome | Protonated weak acid translocates across the plasma membrane

Protonated weak acid translocates across the plasma membrane

Stable Identifier

R-HSA-9737111

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Protonated weak acid translocates across the plasma membrane

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Protonated weak acids such as acetic acid and citric acid are uncharged and are therefore able to diffuse across lipid membranes according to the concentration gradient (Wolosin and Ginsburg 1975, Walter et al. 1982, Walter and Gutknecht 1984, Xiang and Anderson 1998, Grime et al. 2008, Li et al. 2011, Hannesschlaeger et al. 2019). Passive diffusion of weak acids into type III taste cells contributes to sour taste (inferred from rat taste cells).

Literature References

PubMed ID	Title	Journal	Year
7097246	Weak acid permeability through lipid bilayer membranes. Role of chemical reactions in the unstirred layer Walter, A, Hastings, D, Gutknecht, J	J Gen Physiol	1982
6699907	Monocarboxylic acid permeation through lipid bilayer membranes Walter, A, Gutknecht, J	J Membr Biol	1984
237547	The permeation of organic acids through lecithin bilayers. Resemblance to diffusion in polymers Wolosin, JM, Ginsburg, H	Biochim Biophys Acta	1975
30781892	The Effect of Buffers on Weak Acid Uptake by Vesicles Hannesschlaeger, C, Pechova, H, Pohl, P, Barta, T	Biomolecules	2019
9826590	Influence of chain ordering on the selectivity of dipalmitoylphosphatidylcholine bilayer membranes for permeant size and shape Xiang, TX, Anderson, BD	Biophys J	1998
18787114	Quantitative visualization of passive transport across bilayer lipid membranes Edwards, MA, Rudd, NC, Grime, JM, Unwin, PR	Proc Natl Acad Sci U S A	2008
21806938	Imaging molecular transport across lipid bilayers Li, S, Hu, PC, Malmstadt, N	Biophys J	2011