L-Glutamate binds Grm1 (mGluR1)

Stable Identifier
R-RNO-9737052
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
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Medium
High
 | PPTX  | SBGN
L-Glutamate binds Grm1 (mGluR1)
In taste bud cells, L-glutamate binds a truncated isoform of Grm1 (mGluR1) that has about 100x lower affinity for L-glutamate than the full-length, brain-expressed isoform does (San Gabriel et al. 2005, San Gabriel et al. 2009). Binding of L-glutamate to Grm1 activates an incompletely characterized signaling cascade that results in depolarization of the taste bud cell.
Literature References
PubMed ID Title Journal Year
19571209 Metabotropic glutamate receptor type 1 in taste tissue

San Gabriel, A, Uneyama, H, Maekawa, T, Torii, K

Am J Clin Nutr 2009
15738140 Cloning and characterization of a novel mGluR1 variant from vallate papillae that functions as a receptor for L-glutamate stimuli

San Gabriel, A, Yoshie, S, Torii, K, Uneyama, H

Chem Senses 2005
Participants
Input
Output
Orthologous Events
L-Glutamate binds GRM1 (mGluR1) (Homo sapiens)
Authored
May, B  (2021-07-15)
Reviewed
Jiang, P  (2021-08-11)
Created
May, B  (2021-07-16)
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