L-Glutamate binds GRM1 (mGluR1)

Stable Identifier
R-HSA-9737035
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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L-Glutamate binds GRM1 (mGluR1)
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In taste bud cells, L-glutamate binds a truncated isoform of GRM1 (mGluR1) that has about 100x lower affinity for L-glutamate than the full-length, brain-expressed isoform does (inferred from rat homologs). Binding of L-glutamate to GRM1 activates an incompletely characterized signaling cascade that results in depolarization of the taste bud cell.

Literature References
PubMed ID Title Journal Year
15738140 Cloning and characterization of a novel mGluR1 variant from vallate papillae that functions as a receptor for L-glutamate stimuli

San Gabriel, A, Uneyama, H, Yoshie, S, Torii, K

Chem Senses 2005
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Inferred From
L-Glutamate binds Grm1 (mGluR1) (Rattus norvegicus)
Authored
May, B  (2021-07-15)
Reviewed
Jiang, P  (2021-08-11)
Created
May, B  (2021-07-16)
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