Hspa8:Substrate dissociates from Lamp2 multimer

Stable Identifier
R-RNO-9626028
Type
Reaction [dissociation]
Species
Rattus norvegicus
Compartment
lysosomal lumen, lysosomal membrane
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Hspa8:Substrate dissociates from Lamp2 multimer
Heat shock cognate 71 kDa protein (Hspa8) translocates substrates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (Lamp2a). The Lamp2a complex then multimerizes and stabilizes. Subsequently, the substrate unfolds and translocates to the lumen. The substrate bound Hspa8 then dissociates from Lamp2a multimer (Agarraberes FA et al. 1997, Cuervo AM et al. 1997). The function of Lamp2a multimer is now complete and starts to disassemble.
Literature References
PubMed ID Title Journal Year
9151685 An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation

Agarraberes, FA, Terlecky, SR, Dice, JF

J. Cell Biol. 1997
9038169 A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins

Cuervo, AM, Dice, JF, Knecht, E

J. Biol. Chem. 1997
Participants
Input
Output
Orthologous Events
HSPA8:Substrate dissociates from LAMP2a multimer (Homo sapiens)
Authored
Varusai, TM  (2019-11-08)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2018-10-25)
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