HSPA8:Substrate dissociates from LAMP2a multimer

Stable Identifier
R-HSA-9626060
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
lysosomal lumen, lysosomal membrane
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HSPA8:Substrate dissociates from LAMP2a multimer
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Heat shock cognate 71 kDa protein (HSPA8) translocates substrates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). The LAMP2a complex then multimerizes and stabilizes. Subsequently, the substrate unfolds and translocates to the lumen. The substrate bound HSPA8 then dissociates from LAMP2a multimer (Agarraberes FA et al. 1997, Cuervo AM et al. 1997). The function of LAMP2a multimer is now complete and starts to disassemble.

Literature References
PubMed ID Title Journal Year
9038169 A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins

Cuervo, AM, Dice, JF, Knecht, E

J. Biol. Chem. 1997
9151685 An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation

Agarraberes, FA, Terlecky, SR, Dice, JF

J. Cell Biol. 1997
Participants
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Output
Participant Of
hasEvent
Inferred From
Hspa8:Substrate dissociates from Lamp2 multimer (Rattus norvegicus)
Authored
Varusai, TM  (2019-02-21)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2018-10-25)