HSPA8:Substrate dissociates from LAMP2a multimer

Stable Identifier
Reaction [dissociation]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Heat shock cognate 71 kDa protein (HSPA8) translocates substrates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). The LAMP2a complex then multimerizes and stabilizes. Subsequently, the substrate unfolds and translocates to the lumen. The substrate bound HSPA8 then dissociates from LAMP2a multimer (Agarraberes FA et al. 1997, Cuervo AM et al. 1997). The function of LAMP2a multimer is now complete and starts to disassemble.

Literature References
PubMed ID Title Journal Year
9038169 A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins

Cuervo, AM, Dice, JF, Knecht, E

J. Biol. Chem. 1997
9151685 An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation

Agarraberes, FA, Terlecky, SR, Dice, JF

J. Cell Biol. 1997
Participant Of
Inferred From
Cite Us!