Camk1 phosphorylates Arhgef7

Stable Identifier
R-RNO-9619772
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Camk1 phosphorylates Arhgef7
At dendritic spines of rat neurons, Camk1, activated by CaMKK-mediated phosphorylation downstream of NMDA receptor activation, phosphorylates Git1-bound Arhgef7 (beta-PIX) on serine residue S516 (Saneyoshi et al. 2013).
Literature References
PubMed ID Title Journal Year
18184567 Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex

Natsume, T, Fortin, D, Davare, M, Soderling, TR, Nozaki, N, Wayman, G, Saneyoshi, T, Hoshi, N

Neuron 2008
Participants
Input
Output
Catalyst Activity

calmodulin-dependent protein kinase activity of p-T177-Camk1:Calm1:4xCa2+ [cytosol]

Physical Entity
p-T177-Camk1:Calm1:4xCa2+ [cytosol] (Rattus norvegicus)
Activity
calmodulin-dependent protein kinase activity (GO:0004683)
Orthologous Events
CAMK1 phosphorylates ARHGEF7-1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-18)
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