Reactome | CAMK1 phosphorylates ARHGEF7-1

CAMK1 phosphorylates ARHGEF7-1

Stable Identifier

R-HSA-9619783

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        Activation of RAC1 downstream of NMDARs (Homo sapiens)
        
        CAMK1 phosphorylates ARHGEF7-1 (Homo sapiens)

General

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At dendritic spines, CAMK1, activated by CaMKK-mediated phosphorylation downstream of NMDA receptor activation, phosphorylates GIT1-bound ARHGEF7 (beta-PIX) on serine residue S516 (Saneyoshi et al. 2013).

Participants

Input

Output

Participant Of

hasEvent

Activation of RAC1 downstream of NMDARs

Catalyst Activity

Title

calmodulin-dependent protein kinase activity of p-T177-CAMK1:CALM1:4xCa2+ [cytosol]

Physical Entity

p-T177-CAMK1:CALM1:4xCa2+ [cytosol]

Activity

calmodulin-dependent protein kinase activity (0004683)

Inferred From

Camk1 phosphorylates Arhgef7 (Rattus norvegicus)

Authored

Orlic-Milacic, M (2018-10-10)

Reviewed

Yi, F (2018-11-02)

Hansen, KB (2018-11-02)

Created

Orlic-Milacic, M (2018-09-18)