CAMK1 phosphorylates ARHGEF7-1

Stable Identifier
R-HSA-9619783
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CAMK1 phosphorylates ARHGEF7-1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At dendritic spines, CAMK1, activated by CaMKK-mediated phosphorylation downstream of NMDA receptor activation, phosphorylates GIT1-bound ARHGEF7 (beta-PIX) on serine residue S516 (Saneyoshi et al. 2013).

Participants
Input
Output
Participates
as an event of
Catalyst Activity

calmodulin-dependent protein kinase activity of p-T177-CAMK1:CALM1:4xCa2+ [cytosol]

Physical Entity
p-T177-CAMK1:CALM1:4xCa2+ [cytosol] (Homo sapiens)
Activity
calmodulin-dependent protein kinase activity (GO:0004683)
Inferred From
Camk1 phosphorylates Arhgef7 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-18)
Cite Us!