CaM-bound CaMKII-gamma enters the nucleus

Stable Identifier
R-RNO-9618839
Type
Reaction [BlackBoxEvent]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
CaM-bound CaMKII-gamma enters the nucleus

In activated rat neurons, autophosphorylated, calmodulin-bound CaMKII-gamma (Camk2g) translocates to the nucleus (Ma et al. 2014, Cohen et al. 2018).

Literature References
PubMed ID Title Journal Year
29934532 Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory

Cohen, SM, Suutari, B, He, X, Wang, Y, Sanchez, S, Tirko, NN, Mandelberg, NJ, Mullins, C, Zhou, G, Wang, S, Kats, I, Salah, A, Tsien, RW, Ma, H

Nat Commun 2018
25303525 γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression

Ma, H, Groth, RD, Cohen, SM, Emery, JF, Li, B, Hoedt, E, Zhang, G, Neubert, TA, Tsien, RW

Cell 2014
Participants
This event is regulated
Orthologous Events
Authored
Reviewed
Created