GluN1 (Grin1) binds to Actn2

Stable Identifier
R-RNO-9611052
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
plasma membrane
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GluN1 (Grin1) binds to Actn2

In rat neurons, Actn2 (alpha-actinin-2) directly binds to GluN1 (Grin1) subunit of the NMDA receptor, but can also bind to GluN2B (Grin2b). Binding to Actn2 anchors NMDA receptors to the actin cytoskeleton (Wyszynski et al. 1997).

Literature References
PubMed ID Title Journal Year
9009191 Competitive binding of alpha-actinin and calmodulin to the NMDA receptor

Wyszynski, M, Lin, J, Rao, A, Nigh, E, Beggs, AH, Craig, AM, Sheng, M

Nature 1997
Participants
Input
Output
Orthologous Events
GluN1 (GRIN1) binds to ACTN2 at postsynaptic density (Homo sapiens)
Authored
Orlic-Milacic, M  (2019-01-05)
Reviewed
Traynelis, SF  (2019-02-11)
Bhattacharya, S  (2019-02-11)
Camp, C  (2019-02-11)
Created
Orlic-Milacic, M  (2018-06-14)