GluN1 (GRIN1) binds to ACTN2 at postsynaptic density

Stable Identifier
R-HSA-9611030
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GluN1 (GRIN1) binds to ACTN2 at postsynaptic density
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ACTN2 (alpha-actinin-2) directly binds to GluN1 (GRIN1) subunit of the NMDA receptor, but can also bind to GluN2B (GRIN2B) (Wyszynski et al. 1997). Binding to ACTN2 anchors NMDA receptors to the actin cytoskeleton and is needed for the assembly of the postsynaptic density (Wyszynski et al. 1997, Hodges et al. 2014).

Participants
Input
Output
Participant Of
hasEvent
Inferred From
GluN1 (Grin1) binds to Actn2 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2019-01-05)
Reviewed
Traynelis, SF  (2019-02-11)
Bhattacharya, S  (2019-02-11)
Camp, C  (2019-02-11)
Created
Orlic-Milacic, M  (2018-06-14)