Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Rapgef1 [cytosol]
Stable Identifier
R-RNO-913472
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
RAPGEF1, F1M8L9
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
Regulation of signaling by CBL (Rattus norvegicus)
CBL:CRKL binds RAPGEF1 (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Erythropoietin (Rattus norvegicus)
Erythropoietin activates RAS (Rattus norvegicus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Rattus norvegicus)
p-CRKL:RAPGEF1 [cytosol] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Rattus norvegicus)
p-CRKL:RAPGEF1 [cytosol] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by MET (Rattus norvegicus)
MET promotes cell motility (Rattus norvegicus)
MET activates RAP1 and RAC1 (Rattus norvegicus)
RAPGEF1 activates RAP1 (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
RAPGEF1 binds CRK,CRKL (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
Signalling to ERKs (Rattus norvegicus)
Prolonged ERK activation events (Rattus norvegicus)
Frs2-mediated activation (Rattus norvegicus)
p-FRS2:CRKL binds C3G (Rattus norvegicus)
Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
Signaling by PDGF (Rattus norvegicus)
Downstream signal transduction (Rattus norvegicus)
p130Cas and C3G bind PDGFR bound Crk (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase cycle (Rattus norvegicus)
RAC3 GTPase cycle (Rattus norvegicus)
RAC3 binds effectors at the plasma membrane (Rattus norvegicus)
RAC3 effectors [cytosol] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
RAC3:GTP:RAC3 effectors [plasma membrane] (Rattus norvegicus)
RAC3 effectors [cytosol] (Rattus norvegicus)
Rapgef1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:F1M8L9
Gene Names
Rapgef1
Reference Genes
ENSEMBL:ENSRNOG00000014316
UCSC:F1M8L9 Rapgef1
Other Identifiers
10834945
1381643_at
1388249_at
1399140_at
17760703
5645052
5746505
5768774
5902965
5924720
5969153
6189653
6289263
6341894
63881
6502290
6528406
6556547
A_42_P480273
A_43_P15739
A_44_P379699
GE1128496
GO:0001568
GO:0005085
GO:0005515
GO:0005737
GO:0005768
GO:0005769
GO:0007264
GO:0007265
GO:0010976
GO:0030670
GO:0032486
GO:0032991
GO:0038180
GO:0043491
GO:0046328
GO:0046580
GO:0048008
GO:0048471
GO:0048856
GO:0050766
GO:0051898
GO:0060070
GO:0060369
GO:0061028
GO:0061351
GO:0070371
GO:0070373
GO:0070374
GO:0071320
GO:0090090
GO:0098609
GO:1901888
GO:1990090
GO:2000178
PH_rn_0016059
PH_rn_0020698
rc_AI012285_at
Participates
as a component of
p-CRKL:RAPGEF1 [cytosol] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Rattus norvegicus)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Rattus norvegicus)
Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Rattus norvegicus)
as a candidate of
RAC3 effectors [cytosol] (Rattus norvegicus)
as an input of
RAPGEF1 binds CRK,CRKL (Rattus norvegicus)
p130Cas and C3G bind PDGFR bound Crk (Rattus norvegicus)
CBL:CRKL binds RAPGEF1 (Rattus norvegicus)
p-FRS2:CRKL binds C3G (Rattus norvegicus)
Inferred From
RAPGEF1 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSRNOT00000060977
,
ENSRNOG00000014316
,
ENSRNOP00000057696
RGD
619793
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text