Gria2 gene expression is inhibited by Mecp2:Sin3a complex

Stable Identifier
R-RNO-9022366
Type
Reaction [omitted]
Species
Rattus norvegicus
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Gria2 gene expression is inhibited by Mecp2:Sin3a complex
Transcription of rat Gria2 (Glur2) gene, encoding glutamate receptor 2, is inhibited by binding of the rat Mecp2:Sin3a:Hdac1 complex to the promoter of the Gria2 gene (Qiu et al. 2012).
Literature References
PubMed ID Title Journal Year
22262897 The Rett syndrome protein MeCP2 regulates synaptic scaling

Qiu, Z, Sylwestrak, EL, Lieberman, DN, Zhang, Y, Liu, XY, Ghosh, A

J. Neurosci. 2012
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Mecp2:Sin3a:Hdac1:Gria2 gene [nucleoplasm] (Rattus norvegicus)
Active Unit
Mecp2:Sin3a:Hdac1 [nucleoplasm]
Orthologous Events
GRIA2 gene expression is inhibited by MECP2:SIN3A complex (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Christodoulou, J  (2018-08-07)
Krishnaraj, R  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-22)
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