GRIA2 gene expression is inhibited by MECP2:SIN3A complex

Stable Identifier
R-HSA-9022365
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GRIA2 gene expression is inhibited by MECP2:SIN3A complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in rat, transcription of the GRIA2 (GLUR2) gene, encoding glutamate receptor 2, is inhibited by binding of the MECP2:SIN3A:HDAC1 complex to the GRIA2 gene promoter. MECP2-mediated regulation of GRIA2 expression is involved in synaptic scaling (Qiu et al. 2012).
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MECP2:SIN3A:HDAC1:HDAC2:GRIA2 gene [nucleoplasm] (Homo sapiens)
Active Unit
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm]
Inferred From
Gria2 gene expression is inhibited by Mecp2:Sin3a complex (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-22)
Cite Us!