GRIA2 gene expression is inhibited by MECP2:SIN3A complex

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R-HSA-9022365
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Reaction [omitted]
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Homo sapiens
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Based on studies in rat, transcription of the GRIA2 (GLUR2) gene, encoding glutamate receptor 2, is inhibited by binding of the MECP2:SIN3A:HDAC1 complex to the GRIA2 gene promoter. MECP2-mediated regulation of GRIA2 expression is involved in synaptic scaling (Qiu et al. 2012).

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