Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Pten [cytosol]
Stable Identifier
R-RNO-8948777
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
K48polyUb-K289-PTEN, A0A8I6AU71
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
PTEN Regulation (Rattus norvegicus)
Regulation of PTEN stability and activity (Rattus norvegicus)
MKRN1 polyubiquitinates PTEN (Rattus norvegicus)
Pten [cytosol] (Rattus norvegicus)
Proteasome degrades polyubiquitinated PTEN (Rattus norvegicus)
PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Rattus norvegicus)
Pten [cytosol] (Rattus norvegicus)
USP13 and OTUD3 deubiquitinate PTEN (Rattus norvegicus)
Pten [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A8I6AU71
Gene Names
Pten
Reference Genes
ENSEMBL:ENSRNOG00000020723
ENSEMBL:ENSRNOG00000020723.4 Pten
ENSEMBL:ENSRNOG00055029782
ENSEMBL:ENSRNOG00060027159
ENSEMBL:ENSRNOG00065029492
Other Identifiers
10714832
1370112_at
17625048
50557
5727661
5743400
5907266
5984725
6014919
6022657
6032398
6049019
6071241
6106513
6332649
6340362
6361500
6487127
6508687
6598931
6740919
A_43_P12611
GO:0003824
GO:0006629
GO:0008285
GO:0016311
GO:0016314
GO:0016787
GO:0016791
GO:0046856
GO:0051717
GO:0051800
PH_rn_0012064
rc_AA963447_at
Participates
as a member of
PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Rattus norvegicus)
as an output of
MKRN1 polyubiquitinates PTEN (Rattus norvegicus)
as an input of
USP13 and OTUD3 deubiquitinate PTEN (Rattus norvegicus)
Other forms of this molecule
Pten [cytosol]
Pten [nucleoplasm]
phospho-Pten [cytosol]
phospho-Pten [cytosol]
phospho-Pten [cytosol]
phospho-Pten [cytosol]
Pten [cytosol]
Pten [cytosol]
Pten [cytosol]
Pten [nucleoplasm]
Pten [nucleoplasm]
Pten [cytosol]
Inferred From
PolyUb-PTEN,K48polyUb-K289-PTEN [cytosol]
(Homo sapiens)
K48polyUb-K289-PTEN [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 289 (in Homo sapiens)
Coordinate
289
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
Ensembl
ENSRNOP00000097310
,
ENSRNOT00000117228
,
ENSRNOG00000020723
RGD
61995
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text