Reactome | Vamp7 [clathrin-coated endocytic vesicle membrane]

Vamp7 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-RNO-8869135

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

VAMP7, Q9JHW5

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Vamp7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q9JHW5

Gene Names

Vamp7

Reference Genes

BioGPS Gene:85491 Vamp7

ENSEMBL:ENSRNOG00000008372

ENSEMBL:ENSRNOG00055011224

ENSEMBL:ENSRNOG00060024401

ENSEMBL:ENSRNOG00065000037

KEGG:rno:85491 Vamp7

Monarch:85491 Vamp7

NCBI Gene:85491 Vamp7

UCSC:Q9JHW5 Vamp7

Reference Transcript

RefSeq:NM_053531.3 Vamp7

Other Identifiers

10760797

1370098_at

1392903_at

17676488

5628958

5671898

5679285

5689308

6097929

6130911

6136001

6209112

6238869

6268040

6344545

6456419

6638607

85491

A_42_P769921

A_43_P12839

A_44_P995783

GE1208828

GE1241010

GE1242166

GO:0016020

GO:0016192

ILMN_1352570

PH_rn_0011605

rc_AA800822_at

Participates

as a component of

AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Other forms of this molecule

Vamp7 [cytoplasmic vesicle membrane]

Vamp7 [Golgi membrane]

Vamp7 [lysosomal membrane]

Vamp7 [late endosome membrane]

Vamp7 [plasma membrane]

Inferred From

VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_445983.1

ENSEMBL

ENSRNOT00000011065, ENSRNOG00000008372, ENSRNOP00000011065

PRO

Q9JHW5

RGD

621558

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96NW4 ANKRD27	1	ANKRD27 [cytosol] (R-HSA-8876828)	0.581	4
UniProt:P60881	3	Snap25 [plasma membrane] (R-RNO-2029017) Snap25 [specific granule membrane] (R-RNO-6806154) Snap25 [tertiary granule membrane] (R-RNO-6806142)	0.499	2
UniProt:P18708 NSF			0.488	2

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