Reactome | VAMP7 [clathrin-coated endocytic vesicle membrane]

VAMP7 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869135

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Vesicle-associated membrane protein 7, VAMP7_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51809 VAMP7

Gene Names

VAMP7, SYBL1

Chain

initiator methionine:, chain:2-220

Reference Genes

BioGPS Gene:6845 VAMP7

COSMIC (genes):VAMP7 VAMP7

CTD Gene:6845 VAMP7

dbSNP Gene:6845 VAMP7

ENSEMBL:ENSG00000124333 VAMP7

ENSEMBL_homo_sapiens_GENE:ENSG00000124333.16 VAMP7

ENSEMBL_homo_sapiens_GENE:ENSG00000292366.1 VAMP7

HGNC:11486 VAMP7

KEGG Gene (Homo sapiens):6845 VAMP7

Monarch:6845 VAMP7

NCBI Gene:6845 VAMP7

OMIM:300053 VAMP7

UCSC:P51809 VAMP7

Reference Transcript

Other Identifiers

11757799_s_at

17108605

17116684

202829_PM_s_at

202829_s_at

34753_at

3996946

3996947

3996948

3996949

3996950

3996951

3996952

3996960

3996961

3996962

3996963

3996964

4032756

4032757

4032758

4032759

4032760

4032761

4032762

4032770

4032771

4032772

4032773

4032774

6845

8171041

8176962

A_23_P22671

GE60150

GO:0000149

GO:0002376

GO:0005484

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005802

GO:0005886

GO:0006887

GO:0006888

GO:0006906

GO:0006911

GO:0006954

GO:0008333

GO:0015031

GO:0016020

GO:0016192

GO:0017156

GO:0023052

GO:0030027

GO:0030141

GO:0030658

GO:0030667

GO:0030669

GO:0030670

GO:0031091

GO:0031143

GO:0031201

GO:0031410

GO:0031902

GO:0035577

GO:0043005

GO:0043226

GO:0043231

GO:0043308

GO:0043312

GO:0043320

GO:0045202

GO:0045335

GO:0060090

GO:0061024

GO:0070062

GO:0098542

GO:1903595

HMNXSV003026048

ILMN_1690524

PH_hs_0002133

TC0X000792.hg

TC0X001948.hg

TC0Y000109.hg

X92396_at

g5032136_3p_a_at

Participates

as a component of

AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

VAMP7 [late endosome membrane]

VAMP7 [lysosomal membrane]

VAMP7 [plasma membrane]

VAMP7 [Golgi membrane]

VAMP7 [cytoplasmic vesicle membrane]

Inferred To

Vamp7 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

Vamp7 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

VAMP7 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

Ghost homologue of VAMP7 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Cross References

RefSeq

NP_001172112.1, NP_005629.1, NP_001138621.1

OpenTargets

ENSG00000124333

GeneCards

P51809

HPA

ENSG00000124333-VAMP7

Ensembl

ENST00000460621, ENSP00000262640, ENSG00000124333, ENSP00000427822, ENST00000286448, ENST00000262640, ENSP00000286448

PRO

P51809

Pharos - Targets

P51809

Orphanet

22994

PDB

2DMW

HMDB Protein

HMDBP08099

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52594 AGFG1	1	AGFG1 [cytosol] (R-HSA-8863714)	0.639	7
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.602	4
UniProt:Q86Y82 STX12			0.527	4
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.527	2
UniProt:O15400 STX7			0.527	4
UniProt:Q9UNK0 STX8			0.527	2
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.527	2
UniProt:Q5SQN1 SNP47			0.524	4
UniProt:P30153 PPP2R1A	2	PPP2R1A [nucleoplasm] (R-HSA-165968) PPP2R1A [cytosol] (R-HSA-165982)	0.508	2
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.483	2

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