Nrxns binds Munc18

Stable Identifier
R-RNO-6794339
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Nrxns binds Munc18
The cytoplasmic PDZ (PSD-95, Dlg, and ZO-1/2 domain) domain of Neurexin interacts with the intracellular vesicle trafficking protein MUNC18/STXB1 (syntaxin binding peotein) via a multiprotein complex that involves MINT1 and MINT2. MUNC18, a sec1-like protein that is essential for neurotransmitter release exists in complex with Syntaxin (STX1A) and MINT1 and MINT2 in the nervous system (Okamoto & Sudhof 1997, Biederer & Sudhof 2000).
Literature References
PubMed ID Title Journal Year
8786425 CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins

Hata, Y, Butz, S, Südhof, TC

J. Neurosci. 1996
11036064 Mints as adaptors. Direct binding to neurexins and recruitment of munc18

Biederer, T, Südhof, TC

J. Biol. Chem. 2000
Participants
Input
Output
Orthologous Events
NRXNs binds MUNC18 (Homo sapiens)
Authored
Garapati, P V  (2015-09-04)
Reviewed
Washbourne, P  (2015-11-09)
Created
Garapati, P V  (2015-09-04)
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