The cytoplasmic PDZ (PSD-95, Dlg, and ZO-1/2 domain) domain of Neurexin interacts with the intracellular vesicle trafficking protein MUNC18/STXB1 (syntaxin binding peotein) via a multiprotein complex that involves MINT1 and MINT2. MUNC18, a sec1-like protein that is essential for neurotransmitter release exists in complex with Syntaxin (STX1A) and MINT1 and MINT2 in the nervous system (Okamoto & Sudhof 1997, Biederer & Sudhof 2000).
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