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phospho-p-S166,S188-MDM2 [nucleoplasm]
Stable Identifier
R-RNO-6793669
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
A0A8I6G5V3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle Checkpoints (Rattus norvegicus)
G1/S DNA Damage Checkpoints (Rattus norvegicus)
p53-Dependent G1/S DNA damage checkpoint (Rattus norvegicus)
p53-Dependent G1 DNA Damage Response (Rattus norvegicus)
Stabilization of p53 (Rattus norvegicus)
ATM phosphorylates MDM2 (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
MDM2 binds TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
MDM2 forms homo- or heterodimers (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2,MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
MDM2 ubiquitinates TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
MDM2 ubiquitinates phosphorylated MDM4 (Rattus norvegicus)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
Phosphorylation of MDM4 by ATM (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:p-S403-MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
Phosphorylation of MDM4 by CHEK2 (Rattus norvegicus)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:p-S403-MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular Senescence (Rattus norvegicus)
Oncogene Induced Senescence (Rattus norvegicus)
MDM2 ubiquitinates TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
Oxidative Stress Induced Senescence (Rattus norvegicus)
MDM2 ubiquitinates TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Activity through Methylation (Rattus norvegicus)
MDM2 ubiquitinates JMY (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
Regulation of TP53 Activity through Phosphorylation (Rattus norvegicus)
MDM2 ubiquitinates DYRK2 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
Regulation of TP53 Expression and Degradation (Rattus norvegicus)
Regulation of TP53 Degradation (Rattus norvegicus)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
ATM phosphorylates MDM2 (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
CCNG1 recruits PP2A-PPP2R5C to MDM2 (Rattus norvegicus)
PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Rattus norvegicus)
p-T218,S166,S188-MDM2, p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-T218,S166,S188-MDM2, p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
MDM2 binds TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
MDM2 forms homo- or heterodimers (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2,MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
MDM2 homodimers auto-ubiquitinate (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
MDM2 translocates to the nucleus (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
MDM2 ubiquitinates TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
MDM2 ubiquitinates phosphorylated MDM4 (Rattus norvegicus)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
PP2A-PP2R5C dephosphorylates MDM2 (Rattus norvegicus)
PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] (Rattus norvegicus)
p-T218,S166,S188-MDM2, p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
Phosphorylation of MDM4 by ATM (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:p-S403-MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
Phosphorylation of MDM4 by CHEK2 (Rattus norvegicus)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:p-S403-MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
USP7 deubiquitinates MDM2 (Rattus norvegicus)
p-S166,S188-MDM2:(p-S166,S188-MDM2,p-S346,S367,S403-MDM4) [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
Transcriptional regulation by RUNX3 (Rattus norvegicus)
Regulation of RUNX3 expression and activity (Rattus norvegicus)
MDM2 binds RUNX3 (Rattus norvegicus)
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
MDM2 polyubiquitinates RUNX3 (Rattus norvegicus)
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ub-specific processing proteases (Rattus norvegicus)
USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A8I6G5V3
Reference Genes
ENSEMBL:ENSRNOG00000006304
UCSC:A0A8I6G5V3
Participates
as an input of
ATM phosphorylates MDM2 (Rattus norvegicus)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Rattus norvegicus)
MDM2 forms homo- or heterodimers (Rattus norvegicus)
as a candidate of
p-T218,S166,S188-MDM2, p-S166,S188-MDM2 [nucleoplasm] (Rattus norvegicus)
as a component of
p-S166,S188-MDM2:p-S403-MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm] (Rattus norvegicus)
as an output of
MDM2 translocates to the nucleus (Rattus norvegicus)
as a member of
p-S166,S188-MDM2,MDM4 [nucleoplasm] (Rattus norvegicus)
Other forms of this molecule
PolyUb-MDM2 [nucleoplasm]
monoSUMO1-K182-MDM2 [nucleoplasm]
MDM2 [plasma membrane]
MDM2 [endocytic vesicle membrane]
phospho-p-5S,T-MDM2 [nucleoplasm]
phospho-p-S166,S188,T218-MDM2 [nucleoplasm]
phospho-PolyUb,p-S166,S188-MDM2 [nucleoplasm]
MDM2 [nucleoplasm]
MDM2 [cytosol]
phospho-p-S166,S188-MDM2 [cytosol]
Inferred From
p-S166,S188-MDM2 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 166 (in Homo sapiens)
Coordinate
166
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 188 (in Homo sapiens)
Coordinate
188
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
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