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phospho-p-S166,S188-MDM2 [cytosol]
Stable Identifier
R-RNO-198638
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
A0A8I6G5V3
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Expression and Degradation (Rattus norvegicus)
Regulation of TP53 Degradation (Rattus norvegicus)
AKT phosphorylates MDM2 (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [cytosol] (Rattus norvegicus)
MDM2 translocates to the nucleus (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [cytosol] (Rattus norvegicus)
SGK1 phosphorylates MDM2 (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
AKT phosphorylates targets in the cytosol (Rattus norvegicus)
AKT phosphorylates MDM2 (Rattus norvegicus)
phospho-p-S166,S188-MDM2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A8I6G5V3
Reference Genes
ENSEMBL:ENSRNOG00000006304
UCSC:A0A8I6G5V3
Participates
as an input of
MDM2 translocates to the nucleus (Rattus norvegicus)
as an output of
AKT phosphorylates MDM2 (Rattus norvegicus)
SGK1 phosphorylates MDM2 (Rattus norvegicus)
Other forms of this molecule
PolyUb-MDM2 [nucleoplasm]
monoSUMO1-K182-MDM2 [nucleoplasm]
MDM2 [plasma membrane]
MDM2 [endocytic vesicle membrane]
phospho-p-5S,T-MDM2 [nucleoplasm]
phospho-p-S166,S188,T218-MDM2 [nucleoplasm]
phospho-PolyUb,p-S166,S188-MDM2 [nucleoplasm]
MDM2 [nucleoplasm]
MDM2 [cytosol]
phospho-p-S166,S188-MDM2 [nucleoplasm]
Inferred From
p-S166,S188-MDM2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 166 (in Homo sapiens)
Coordinate
166
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 188 (in Homo sapiens)
Coordinate
188
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
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