PIKE-L interaction with UNC5B

Stable Identifier
R-RNO-622360
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PIKE-L interaction with UNC5B
PIKE-L a brain-specific GTPase selectively associates with UNC5B but not with other family members of UNC5. Netrin-1 enhances this interaction and this interaction triggers the activation of PI3K kinase signalling, prevents UNC5B's pro-apoptotic activity and enhances neuronal survival.
Literature References
PubMed ID Title Journal Year
18469807 Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B

Okada, M, Rama, N, Mehlen, P, Liu, Y, Luo, SW, Jang, SW, Xiong, WC, Chan, CB, Feng, Y, Ye, K, Hong, Y, Tang, X

Nat Cell Biol 2008
Participants
Input
Output
Orthologous Events
PIKE-L interaction with UNC5B (Homo sapiens)
Authored
Garapati, P V  (2010-04-13)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2010-04-23)
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