PIKE-L interaction with UNC5B

Stable Identifier
R-HSA-622357
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIKE-L a brain-specific GTPase selectively associates with UNC5B but not with other family members of UNC5. Netrin-1 enhances this interaction and this interaction triggers the activation of PI3K kinase signalling, prevents UNC5B's pro-apoptotic activity and enhances neuronal survival.

Participants
Participant Of
Inferred From
Authored
Reviewed
Created
Cite Us!